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dc.contributor.author
Herzog, Rubén
dc.contributor.author
Mediano, Pedro A. M.
dc.contributor.author
Rosas, Fernando E.
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Carhart-Harris, Robin
dc.contributor.author
Sanz Perl Hernandez, Yonatan
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dc.contributor.author
Tagliazucchi, Enzo Rodolfo
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dc.contributor.author
Cofre, Rodrigo
dc.date.available
2021-11-05T11:59:44Z
dc.date.issued
2020-10
dc.identifier.citation
Herzog, Rubén; Mediano, Pedro A. M.; Rosas, Fernando E.; Carhart-Harris, Robin; Sanz Perl Hernandez, Yonatan; et al.; A mechanistic model of the neural entropy increase elicited by psychedelic drugs; Nature Publishing Group; Scientific Reports; 10; 1; 10-2020; 1-12
dc.identifier.issn
2045-2322
dc.identifier.uri
http://hdl.handle.net/11336/146089
dc.description.abstract
Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in some regions and decreased in others, suggesting a topographical reconfiguration mediated by 5HT2A-R activation. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain’s anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LSD
dc.subject
Neuroimaging
dc.subject
Modeling
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Entropy
dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
A mechanistic model of the neural entropy increase elicited by psychedelic drugs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T18:21:56Z
dc.journal.volume
10
dc.journal.number
1
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Herzog, Rubén. Universidad de Valparaíso; Chile
dc.description.fil
Fil: Mediano, Pedro A. M.. University of Cambridge; Estados Unidos
dc.description.fil
Fil: Rosas, Fernando E.. Imperial College London; Reino Unido
dc.description.fil
Fil: Carhart-Harris, Robin. Imperial College London; Reino Unido
dc.description.fil
Fil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
dc.description.fil
Fil: Cofre, Rodrigo. Universidad de Valparaíso; Chile
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-020-74060-6
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