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Artículo

A New Cage-Like Particle Adjuvant Enhances Protection of Foot-and-Mouth Disease Vaccine

Bidart, Juan EstebanIcon ; Kornuta, Claudia AlejandraIcon ; Gammella, Mariela Vanesa; Gnazzo, VictoriaIcon ; Soria, IvanaIcon ; Langellotti, Cecilia AnaIcon ; Mongini, ClaudiaIcon ; Galarza, Roxana; Calvinho, Luis Fernando; Lupi, Giuliana AntonellaIcon ; Quattrocchi, ValeriaIcon ; Marcipar, Iván SergioIcon ; Zamorano, Patricia InesIcon
Fecha de publicación: 07/2020
Editorial: Frontiers Media
Revista: Frontiers in Veterinary Science
ISSN: 2297-1769
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Ciencias Veterinarias

Resumen

Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model to predict their effectiveness in cattle. Immunostimulant Particle Adjuvant (ISPA), also known as cage-like particle adjuvant, consisting of lipid boxes of dipalmitoyl-phosphatidylcholine, cholesterol, sterylamine, alpha-tocopherol, and QuilA saponin, was shown to enhance protection of a recombinant vaccine against Trypanosoma cruzi in a mouse model. Thus, in the present work, we studied the effects on the magnitude and type of immunity elicited in mice and cattle in response to a vaccine based on inactivated FMD virus (iFMDV) formulated with ISPA. It was demonstrated that iFMDV–ISPA induced protection in mice against challenge and elicited a specific antibody response in sera, characterized by a balanced Th1/Th2 profile. In cattle, the antibody titers reached corresponded to an expected percentage of protection (EPP) higher than 80%. EPP calculates the probability that livestock would be protected against a 10,000 bovine infectious doses challenge after vaccination. Moreover, in comparison with the non-adjuvanted iFMDV vaccine, iFMDV–ISPA elicited an increased specific T-cell response against the virus, including higher interferon gamma (IFNγ)+/CD8+ lymphocyte production in cattle. In this work, we report for first time that an inactivated FMDV serotype A vaccine adjuvanted with ISPA is capable of inducing protection against challenge in a murine model and of improving the specific immune responses against the virus in cattle.
Palabras clave: ADJUVANT , FMDV , IMMUNE RESPONCE , ISPA , PROTECTION , VACCINE
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/145977
URL: https://www.frontiersin.org/article/10.3389/fvets.2020.00396/full
DOI: http://dx.doi.org/10.3389/fvets.2020.00396
Colecciones
Articulos (IVIT)
Articulos de INSTITUTO DE VIROLOGIA E INNOVACIONES TECNOLOGICAS
Articulos(IBS)
Articulos de INSTITUTO DE BIOLOGIA SUBTROPICAL
Citación
Bidart, Juan Esteban; Kornuta, Claudia Alejandra; Gammella, Mariela Vanesa; Gnazzo, Victoria; Soria, Ivana; et al.; A New Cage-Like Particle Adjuvant Enhances Protection of Foot-and-Mouth Disease Vaccine; Frontiers Media; Frontiers in Veterinary Science; 7; 7-2020; 1-12
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