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dc.contributor.author
Eschenroeder, Andrew C.
dc.contributor.author
Vestal Laborde, Allison A.
dc.contributor.author
Sanchez, Emilse Silvina
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dc.contributor.author
Robinson, Susan E.
dc.contributor.author
Sato Bigbee, Carmen
dc.date.available
2017-03-31T16:17:49Z
dc.date.issued
2011-01
dc.identifier.citation
Eschenroeder, Andrew C.; Vestal Laborde, Allison A.; Sanchez, Emilse Silvina; Robinson, Susan E.; Sato Bigbee, Carmen; Oligodendrocyte responses to buprenorphine uncover novel and opposing roles of μ-opioid- and nociceptin/orphanin FQ receptors in cell development: Implications for drug addiction treatment during pregnancy; Wiley; Glia; 60; 1; 1-2011; 125-136
dc.identifier.issn
0894-1491
dc.identifier.uri
http://hdl.handle.net/11336/14592
dc.description.abstract
Although the classical function of myelin is the facilitation of saltatory conduction, this membrane and the oligodendrocytes, the cells that make myelin in the central nervous system (CNS), are now recognized as important regulators of plasticity and remodeling in the developing brain. As such, oligodendrocyte maturation and myelination are among the most vulnerable processes along CNS development. We have shown previously that rat brain myelination is significantly altered by buprenorphine, an opioid analogue currently used in clinical trials for managing pregnant opioid addicts. Perinatal exposure to low levels of this drug induced accelerated and increased expression of myelin basic proteins (MBPs), cellular and myelin components that are markers of mature oligodendrocytes. In contrast, supra-therapeutic drug doses delayed MBP brain expression and resulted in a decreased number of myelinated axons. We have now found that this biphasic-dose response to buprenorphine can be attributed to the participation of both the mu-opioid receptor (MOR) and the nociceptin/orphanin FQ receptor (NOP receptor) in the oligodendrocytes. This is particularly intriguing because the NOP receptor/ nociceptin system has been primarily linked to behavior and pain regulation, but a role in CNS development or myelination has not been described before. Our findings suggest that balance between signaling mediated by (a) MOR activation and (b) a novel, yet unidentified pathway that includes the NOP receptor, plays a crucial role in the timing of oligodendrocyte maturation and myelin synthesis. Moreover, exposure to opioids could disrupt the normal interplay between these two systems altering the developmental pattern of brain myelination.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Myelination
dc.subject
Myelin
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Oligodendrocytes
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Opioids And Pregnancy
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Addiction Treatment
dc.subject.classification
Drogadicción
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Oligodendrocyte responses to buprenorphine uncover novel and opposing roles of μ-opioid- and nociceptin/orphanin FQ receptors in cell development: Implications for drug addiction treatment during pregnancy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-30T17:42:34Z
dc.identifier.eissn
1098-1136
dc.journal.volume
60
dc.journal.number
1
dc.journal.pagination
125-136
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Eschenroeder, Andrew C.. Virginia Commonwealth University School Of Medicine; Estados Unidos
dc.description.fil
Fil: Vestal Laborde, Allison A.. Virginia Commonwealth University School Of Medicine; Estados Unidos
dc.description.fil
Fil: Sanchez, Emilse Silvina. Virginia Commonwealth University School Of Medicine; Estados Unidos. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Robinson, Susan E.. Virginia Commonwealth University School Of Medicine; Estados Unidos
dc.description.fil
Fil: Sato Bigbee, Carmen. Virginia Commonwealth University School Of Medicine; Estados Unidos
dc.journal.title
Glia
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/glia.21253/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/glia.21253
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