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dc.contributor.author
Navigatore Fonzo, Lorena Silvina
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dc.contributor.author
Delgado, Silvia M.
dc.contributor.author
Golini, Rebeca Laura Susana
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dc.contributor.author
Anzulovich Miranda, Ana Cecilia
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dc.date.available
2017-03-31T15:24:01Z
dc.date.issued
2014-04
dc.identifier.citation
Navigatore Fonzo, Lorena Silvina; Delgado, Silvia M.; Golini, Rebeca Laura Susana; Anzulovich Miranda, Ana Cecilia; Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A-deficient rats; Elsevier Inc; Nutrition Research; 34; 4; 4-2014; 326-335
dc.identifier.issn
0271-5317
dc.identifier.uri
http://hdl.handle.net/11336/14589
dc.description.abstract
The main external time giver is the day-night cycle; however, signals from feeding and the activity/rest cycles can entrain peripheral clocks, such as the hippocampus, in the absence of light. Knowing that vitamin A and its derivatives, the retinoids, may act as regulators of the endogenous clock activity, we hypothesized that the nutritional deficiency of vitamin A may influence the locomotor activity rhythm as well as the endogenous circadian patterns of clock genes in the rat hippocampus. Locomotor activity was recorded during the last week of the treatment period. Circadian rhythms of clock genes expression were analyzed by reverse transcription–polymerase chain reaction in hippocampus samples that were isolated every 4 hours during a 24-hour period. Reduced glutathione (GSH) levels were also determined by a kinetic assay. Regulatory regions of clock PER2, CRY1, and CRY2 genes were scanned for RXRE, RARE, and RORE sites. As expected, the locomotor activity pattern of rats shifted rightward under constant dark conditions. Clock genes expression and GSH levels displayed robust circadian oscillations in the rat hippocampus. We found RXRE and RORE sites on regulatory regions of clock genes. Vitamin A deficiency dampened rhythms of locomotor activity as well as modified endogenous rhythms of clock genes expression and GSH levels. Thus, vitamin A may have a role in endogenous clock functioning and participate in the circadian regulation of the cellular redox state in the hippocampus, a peripheral clock with relevant function in memory and learning.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Circadian Rhythm
dc.subject
Locomotor Activity
dc.subject
Endogenous Clock
dc.subject
Hippocampus
dc.subject
Activiy/Rest Cycle
dc.subject
Biological Rhythm
dc.subject
Cry
dc.subject
Vitamin A-Deficient Rats
dc.subject
Per
dc.subject.classification
Biología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A-deficient rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-30T17:43:25Z
dc.journal.volume
34
dc.journal.number
4
dc.journal.pagination
326-335
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Navigatore Fonzo, Lorena Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis; Argentina
dc.description.fil
Fil: Delgado, Silvia M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
dc.description.fil
Fil: Golini, Rebeca Laura Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis; Argentina
dc.description.fil
Fil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis; Argentina
dc.journal.title
Nutrition Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0271531714000232
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.nutres.2014.02.002
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