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dc.contributor.author
Denninghoff, Valeria Cecilia
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dc.contributor.author
Muino, A.
dc.contributor.author
Diaz, M.
dc.contributor.author
Harada, L.
dc.contributor.author
Lence, A.
dc.contributor.author
Turon, P.
dc.contributor.author
Labbrozzi, M.
dc.contributor.author
Aguas, S.
dc.contributor.author
Peñaloza, P.
dc.contributor.author
Avagnina, A.
dc.contributor.author
Adler, I.
dc.date.available
2021-11-03T18:50:18Z
dc.date.issued
2020-01
dc.identifier.citation
Denninghoff, Valeria Cecilia; Muino, A.; Diaz, M.; Harada, L.; Lence, A.; et al.; Mutational status of PIK3ca oncogene in oral cancer—In the new age of PI3K inhibitors; Elsevier Gmbh; Pathology - Research And Practice; 216; 1; 1-2020; 1-5
dc.identifier.issn
0344-0338
dc.identifier.uri
http://hdl.handle.net/11336/145880
dc.description.abstract
In the new age of PI3K inhibitors, the mutational status of PI3Kca oncogene in the Cavity Squamous Cell Carcinoma (OC-SCC) needs further analysis. It is the sixth most common cancer in the world. The aim of this study was to evaluate PI3Kca oncogene mutations and to correlate them with the clinical-histological characteristics of individuals presenting these tumors. We recruited 74 individuals with OC-SCC diagnosis (period 2000–2014). Histological sections were used. DNA was purified; PIK3ca gene exons 9 and 20 were amplified and sequenced. In 49/74 cases (66 %), the complete sequence of both codons was analyzed by Sanger method. We found that 7/49 (14 %) individuals mutated. In exon 9 we found 1/49 (2 %), and in exon 20 M1043I 8/49 (16 %). We have found the coexistence of more than one mutation in a same individual (E542 K and M1043I). A positive association was observed between the mutational status of the codon 9 (E542 K) and the tongue location. In conclusion, the frequency of PI3Kca gene mutation in OC-SCC was 16 %, which is similar to that reported for other populations. We found a mutation not previously described (M1043I) in this pathology. Should its biological effect be confirmed, it must be added to the list of PIK3ca mutations. Total mutations in the PIK3ca were 32 %, with tongue being the site at the greatest risk (E542K-E545K-M1043I). These findings would facilitate the identification of patients with therapeutic targets in the near future.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Gmbh
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ORAL CANCER
dc.subject
PI3K
dc.subject
TONGUE
dc.subject.classification
Oncología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Mutational status of PIK3ca oncogene in oral cancer—In the new age of PI3K inhibitors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T15:00:48Z
dc.journal.volume
216
dc.journal.number
1
dc.journal.pagination
1-5
dc.journal.pais
Alemania
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dc.description.fil
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
dc.description.fil
Fil: Muino, A.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Diaz, M.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Harada, L.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Lence, A.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Turon, P.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Labbrozzi, M.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Aguas, S.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Peñaloza, P.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.description.fil
Fil: Avagnina, A.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.description.fil
Fil: Adler, I.. Universidad de Buenos Aires; Argentina
dc.journal.title
Pathology - Research And Practice
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0344033819316255
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.prp.2019.152777
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