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dc.contributor.author
Gimeno Valiente, F.  
dc.contributor.author
Riffo Campos, Á. L.  
dc.contributor.author
Ayala, G.  
dc.contributor.author
Tarazona, N.  
dc.contributor.author
Gambardella, V.  
dc.contributor.author
Rodríguez, Fernanda Mariel  
dc.contributor.author
Huerta, M.  
dc.contributor.author
Martínez-Ciarpaglini, C.  
dc.contributor.author
Montón Bueno, J.  
dc.contributor.author
Roselló, S.  
dc.contributor.author
Roda, D.  
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Cervantes, A.  
dc.contributor.author
Franco, L.  
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López Rodas, G.  
dc.contributor.author
Castillo, J.  
dc.date.available
2021-11-02T11:31:12Z  
dc.date.issued
2020-02  
dc.identifier.citation
Gimeno Valiente, F.; Riffo Campos, Á. L.; Ayala, G.; Tarazona, N.; Gambardella, V.; et al.; EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness; Nature Publishing Group; Scientific Reports; 10; 1; 2-2020; 1-14  
dc.identifier.issn
2045-2322  
dc.identifier.uri
http://hdl.handle.net/11336/145682  
dc.description.abstract
The finding of novel molecular markers for prediction or prognosis of invasiveness in colorectal cancer (CRC) constitutes an appealing challenge. Here we show the up-regulation of EPDR1 in a prospective cohort of 101 CRC patients, in a cDNA array of 43 patients and in in silico analyses. EPDR1 encodes a protein related to ependymins, a family of glycoproteins involved in intercellular contacts. A thorough statistical model allowed us to conclude that the gene is significantly up-regulated in tumour tissues when compared with normal mucosa. These results agree with those obtained by the analysis of three publicly available databases. EPDR1 up-regulation correlates with the TNM staging parameters, especially T and M. Studies with CRC cell lines revealed that the methylation of a CpG island controls EPDR1 expression. siRNA knocking-down and overexpression of the gene following transient plasmid transfection, showed that EPDR1 favours cell proliferation, migration, invasiveness and adhesion to type I collagen fibres, suggesting a role in epithelial to mesenchymal transition. Both statistical and functional analysis correlated EPDR1 overexpression with invasiveness and dissemination of tumour cells, supporting the inclusion of EPDR1 in panels of genes used to improve molecular subtyping of CRC. Eventually, EPDR1 may be an actionable target.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Nature Publishing Group  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
EPDR1  
dc.subject
colorectal  
dc.subject
cancer  
dc.subject
human  
dc.subject.classification
Otras Ciencias de la Salud  
dc.subject.classification
Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-04-28T20:42:36Z  
dc.journal.volume
10  
dc.journal.number
1  
dc.journal.pagination
1-14  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Gimeno Valiente, F.. No especifíca;  
dc.description.fil
Fil: Riffo Campos, Á. L.. Universidad de La Frontera; Chile  
dc.description.fil
Fil: Ayala, G.. Universidad de Valencia; España  
dc.description.fil
Fil: Tarazona, N.. Universidad de Valencia; España  
dc.description.fil
Fil: Gambardella, V.. Universidad de Valencia; España  
dc.description.fil
Fil: Rodríguez, Fernanda Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina  
dc.description.fil
Fil: Huerta, M.. Universidad de Valencia; España  
dc.description.fil
Fil: Martínez-Ciarpaglini, C.. Universidad de Valencia; España  
dc.description.fil
Fil: Montón Bueno, J.. Universidad de Valencia; España  
dc.description.fil
Fil: Roselló, S.. Universidad de Valencia; España  
dc.description.fil
Fil: Roda, D.. Universidad de Valencia; España  
dc.description.fil
Fil: Cervantes, A.. Universidad de Valencia; España  
dc.description.fil
Fil: Franco, L.. Universidad de Valencia; España  
dc.description.fil
Fil: López Rodas, G.. Universidad de Valencia; España  
dc.description.fil
Fil: Castillo, J.. Universidad de Valencia; España  
dc.journal.title
Scientific Reports  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-020-60476-7  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-020-60476-7