Capítulo de Libro
Neuroendocrine-immune interactions: impact of gender, negative energetic balance condition, and developmental stage on the mechanisms of the acute phase response of the inflammatory process in mammals
Título del libro: Developmental immunotoxicology
Fecha de publicación:
2004
Editorial:
CRC Press - Taylor & Francis Group
ISBN:
0-415-28457-0
Idioma:
Inglés
Clasificación temática:
Resumen
The discovery of a negative feedback loop between the immune system and the brain (Besedovsky et al. 1986; Fauci 1979; Sapolsky et al. 1987) is one of the most exciting advances in the field of neuroendocrine-immunology. Immune cells can be stimulated by microorganism-derived toxins to secrete cytokines (Dinarello and Mier 1987). In turn, cytokines may induce many host responses associated with endotoxemia (Michalek et al. 1980), characterized by fever, stress hormone release, mineral redistribution, and increased acute phase protein synthesis (Dinarello 1988). The proinflammatory cytokines, interleukin (IL)-1 (Girardin et al. 1988), and tumor necrosis factor alpha (TNF) a (Michie et al. 1988) have been proposed to be the most important mediators for the development of the above-mentioned pathophysiological responses.
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Capítulos de libros(CENEXA)
Capítulos de libros de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Capítulos de libros de CENTRO DE ENDOCRINOLOGIA EXP.Y APLICADA (I)
Citación
Spinedi, Eduardo Julio; Perez, Néstor B.; Gaillard, Rolf; Neuroendocrine-immune interactions:
impact of gender, negative energetic
balance condition, and developmental
stage on the mechanisms of the acute
phase response of the inflammatory
process in mammals; CRC Press - Taylor & Francis Group; 2004; 303-353
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