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dc.contributor.author
Bettucci, Gabriel Roberto
dc.contributor.author
Rodriguez, María Victoria
dc.contributor.author
Frediani Ferretti, Matías Daniel
dc.contributor.author
Campagna, Maria Noel
dc.contributor.author
Monti, Juan Alberto
dc.contributor.author
Carnovale, Cristina Ester
dc.contributor.author
Alvarez, María de Luján
dc.contributor.author
Martínez, María Laura
dc.date.available
2021-10-29T15:18:58Z
dc.date.issued
2020-02
dc.identifier.citation
Bettucci, Gabriel Roberto; Rodriguez, María Victoria; Frediani Ferretti, Matías Daniel; Campagna, Maria Noel; Monti, Juan Alberto; et al.; Choleretic Properties of Baccharis spicata Aerial Parts Extracts in Male Wistar Rats; Springer; Revista Brasileira de Farmacognosia; 30; 1; 2-2020; 54-60
dc.identifier.issn
1981-528X
dc.identifier.uri
http://hdl.handle.net/11336/145471
dc.description.abstract
Many Baccharis species, Asteraceae, called “carquejas” are traditional folk herbs used for the treatment of hepatic disorders in South American countries. Baccharis articulata (Lam.) Pers. and B. crispa Spreng. are included in the Argentine Pharmacopeia. However, the analysis of commercial samples showed that B. spicata (Lam.) Baill. often replaces official Baccharis spp. although there are no scientific studies that support its use. In this work, Wistar rats were administered with different doses of ethanol extract form aerial parts and its derived aqueous and ethylacetate extracted fractions. We determined that the bile flow significantly increased when the ethanol extract-treated groups were compared with the control. Moreover, the aqueous and ethylacetate fractions induced an increase not only in bile flow compared with the control group, but also in the biliary excretion of bile salts. In addition, the ethanol extract and ethylacetate fraction significantly induced expression of cholesterol 7α-hydroxylase (CYP7A, the enzyme that initiates the classic bile acid biosynthetic pathway), suggesting that both treatments can induce bile secretion through a bile salt-dependent mechanism. In order to provide a chemical analysis useful for the quality control of B. spicata extract and fractions, HPLC-UV/DAD and HPLC-MS were carried out. Our results demonstrate that the aqueous fraction was enriched in monocaffeoylquinic acids and the ethylacetate fraction in dicaffeoylquinic acids. The obtained results suggest that B. spicata-derived extracts cause a significant increase in bile flow as well as in bile salts concentration, demonstrating a choleretic activity produced by caffeoylquinic acids.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Asteraceae
dc.subject
Baccharis spicata
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Choleretic activity
dc.subject
monocaffeoylquinic acids
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Choleretic Properties of Baccharis spicata Aerial Parts Extracts in Male Wistar Rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T20:37:03Z
dc.journal.volume
30
dc.journal.number
1
dc.journal.pagination
54-60
dc.journal.pais
Brasil
dc.description.fil
Fil: Bettucci, Gabriel Roberto. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas.; Argentina
dc.description.fil
Fil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Frediani Ferretti, Matías Daniel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas.; Argentina
dc.description.fil
Fil: Campagna, Maria Noel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas.; Argentina
dc.description.fil
Fil: Monti, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
dc.description.fil
Fil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
dc.description.fil
Fil: Alvarez, María de Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
dc.description.fil
Fil: Martínez, María Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas.; Argentina
dc.journal.title
Revista Brasileira de Farmacognosia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s43450-020-00021-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s43450-020-00021-9
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