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dc.contributor.author
Cassanelli, Pablo Martín
dc.contributor.author
Cladouchos, María Laura
dc.contributor.author
Fernández Macedo, Georgina Valeria
dc.contributor.author
Sifonios, Laura Lucrecia
dc.contributor.author
Giaccardi, Laura Inés
dc.contributor.author
Gutiérrez, María Laura
dc.contributor.author
Gravielle, Maria Clara
dc.contributor.author
Wikinski, Silvia Ines
dc.date.available
2017-03-30T19:05:14Z
dc.date.issued
2015-07
dc.identifier.citation
Cassanelli, Pablo Martín; Cladouchos, María Laura; Fernández Macedo, Georgina Valeria; Sifonios, Laura Lucrecia; Giaccardi, Laura Inés; et al.; Working memory training triggers delayed chromatin remodeling in the mouse corticostriatothalamic circuit; Elsevier Inc; Progress of Neuro-psychopharmacology and Biological Psychiatry; 60; 7-2015; 93-103
dc.identifier.issn
0278-5846
dc.identifier.uri
http://hdl.handle.net/11336/14540
dc.description.abstract
Working memory is a cognitive function serving goal-oriented behavior. In the last decade, working memory training has been shown to improve performance and its efficacy for the treatment of several neuropsychiatric disorders has begun to be examined. Neuroimaging studies have contributed to elucidate the brain areas involved but little is known about the underlying cellular events. A growing body of evidence has provided a link between working memory and relatively long-lasting epigenetic changes. However, the effects elicited by working memory training at the epigenetic level remain unknown. In this study we establish an animal model of working memory training and explore the changes in histone H3 acetylation (H3K9,14Ac) and histone H3 dimethylation on lysine 27 (H3K27Me2) triggered by the procedure in the brain regions of the corticostriatothalamic circuit (prelimbic/infralimbic cortex (PrL/IL), dorsomedial striatum (DMSt) and dorsomedial thalamus (DMTh)). Mice trained on a spontaneous alternation task showed improved alternation scores when tested with a retention interval that disrupts the performance of untrained animals. We then determined the involvement of the brain areas of the corticostriatothalamic circuit in working memory training by measuring the marker of neuronal activation c-fos. We observed increased c-fos levels in PrL/IL and DMSt in trained mice 90 min after training. These animals also presented lower immunoreactivity for H3K9,14Ac in DMSt 24 h but not 90 min after the procedure. Increases in H3K27Me2, a repressive chromatin mark, were found in the DMSt and DMTh 24 h after the task. Altogether, we present a mouse model to study the cellular underpinnings of working memory training and provide evidence indicating delayed chromatin remodeling towards repression triggered by the procedure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
C-Fos
dc.subject
Executive Function
dc.subject
Histone Acetylation
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Histone Methylation
dc.subject
Neural Network
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Working memory training triggers delayed chromatin remodeling in the mouse corticostriatothalamic circuit
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-06T17:07:28Z
dc.journal.volume
60
dc.journal.pagination
93-103
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Cassanelli, Pablo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina; Argentina
dc.description.fil
Fil: Cladouchos, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina; Argentina
dc.description.fil
Fil: Fernández Macedo, Georgina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina; Argentina
dc.description.fil
Fil: Sifonios, Laura Lucrecia.
dc.description.fil
Fil: Giaccardi, Laura Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina; Argentina
dc.description.fil
Fil: Gutiérrez, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina; Argentina
dc.description.fil
Fil: Gravielle, Maria Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina; Argentina
dc.description.fil
Fil: Wikinski, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina
dc.journal.title
Progress of Neuro-psychopharmacology and Biological Psychiatry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584615000445
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pnpbp.2015.02.011
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