Artículo
HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
Cambiagno, Damián Alejandro
; Giudicatti, Axel Joel
; Arce, Agustín Lucas
; Gagliardi, Delfina
; Li, Lei; Yuan, Wei; Lundberg, Derek S.; Weigel, Detlef; Manavella, Pablo Andrés
Fecha de publicación:
03/2021
Editorial:
Oxford University Press
Revista:
Molecular Plant
ISSN:
1674-2052
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator at MIRNA loci, thereby acting as a linker between pri-miRNA transcription and processing.
Palabras clave:
GENE SILENCING
,
HASTY
,
MICRORNA
,
MIRNA BIOGENESIS
,
MIRNA NUCLEAR EXPORT
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Licencia
Identificadores
Colecciones
Articulos (UDEA)
Articulos de UNIDAD DE ESTUDIOS AGROPECUARIOS
Articulos de UNIDAD DE ESTUDIOS AGROPECUARIOS
Articulos(IAL)
Articulos de INSTITUTO DE AGROBIOTECNOLOGIA DEL LITORAL
Articulos de INSTITUTO DE AGROBIOTECNOLOGIA DEL LITORAL
Citación
Cambiagno, Damián Alejandro; Giudicatti, Axel Joel; Arce, Agustín Lucas; Gagliardi, Delfina; Li, Lei; et al.; HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing; Oxford University Press; Molecular Plant; 14; 3; 3-2021; 426-439
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