Artículo
Understanding the glioblastoma tumor biology to optimize photodynamic therapy: From molecular to cellular events
Ibarra, Luis Exequiel
; Vilchez, Maria Laura
; Caverzan, Matias Daniel
; Milla Sanabria, Laura Natalia
Fecha de publicación:
12/2020
Editorial:
Wiley-liss, div John Wiley & Sons Inc.
Revista:
Journal of Neuroscience Research
ISSN:
0360-4012
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Photodynamic therapy (PDT) has recently gained attention as an alternative treatment of malignant gliomas. Glioblastoma (GBM) is the most prevalent within tumors of the central nervous system (CNS). Conventional treatments for this CNS tumor include surgery, radiation, and chemotherapy. Surgery is still being considered as the treatment of choice. Even so, the poor prognosis and/or recurrence of the disease after applying any of these treatments highlight the urgency of exploring new therapies and/or improving existing ones to achieve the definitive eradication of tumor masses and remaining cells. PDT is a therapeutic modality that involves the destruction of tumor cells by reactive oxygen species induced by light, which were previously treated with a photosensitizing agent. However, in recent years, its experimental application has expanded to other effects that could improve overall performance against GBM. In the current review, we revisit the main advances of PDT for GBM management and also, the recent mechanistic insights about cellular and molecular aspects related to tumoral resistance to PDT of GBM.
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Articulos (INBIAS)
Articulos de INSTITUTO DE BIOTECNOLOGIA AMBIENTAL Y SALUD
Articulos de INSTITUTO DE BIOTECNOLOGIA AMBIENTAL Y SALUD
Citación
Ibarra, Luis Exequiel; Vilchez, Maria Laura; Caverzan, Matias Daniel; Milla Sanabria, Laura Natalia; Understanding the glioblastoma tumor biology to optimize photodynamic therapy: From molecular to cellular events; Wiley-liss, div John Wiley & Sons Inc.; Journal of Neuroscience Research; 99; 4; 12-2020; 1024-1047
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