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dc.contributor.author
Paredes, Alfonso H.
dc.contributor.author
Salvetti, Natalia Raquel
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dc.contributor.author
Diaz, Ariel E.
dc.contributor.author
Dallard, Bibiana Elisabet
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dc.contributor.author
Ortega, Hugo Hector
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dc.contributor.author
Lara, Hernán H.
dc.date.available
2017-03-30T14:00:55Z
dc.date.issued
2011-04
dc.identifier.citation
Paredes, Alfonso H.; Salvetti, Natalia Raquel; Diaz, Ariel E.; Dallard, Bibiana Elisabet; Ortega, Hugo Hector; et al.; Sympathetic nerve activity in normal and cystic follicles from isolated bovine ovary: local effect of beta-adrenergic stimulation on steroid secretion; Biomed Central; Reproductive Biology And Endocrinology; 9; 66; 4-2011; 1-8
dc.identifier.uri
http://hdl.handle.net/11336/14505
dc.description.abstract
Cystic ovarian disease (COD) is an important cause of abnormal estrous behavior and infertility in dairy cows. COD is mainly observed in high-yielding dairy cows during the first months postpartum, a period of high stress. We have previously reported that, in lower mammals, stress induces a cystic condition similar to the polycystic ovary syndrome in humans and that stress is
a definitive component in the human pathology. To know if COD in cows is also associated with high sympathetic activity, we studied isolated small antral (5mm), preovulatory (10mm) and cystic follicles (25mm). Cystic follicles which present an area 600 fold greater compared with preovulatory follicles has only 10 times less concentration of NE as compared with small antral and preovulatory follicles but they had 10 times more NE in follicular fluid, suggesting a high
efflux of neurotransmitter from the cyst wall. This suggestion was reinforced by the high basal release of recently taken-up 3H-NE found in cystic follicles. While lower levels of beta adrenergic receptor were found in cystic follicles, there was a heightened response to the beta-adrenergic agonist isoproterenol and to hCG, as measured by testosterone secretion. There was however an unexpected capacity of the ovary in vitro to produce cortisol and to secrete it in response to hCG but not to isoproterenol. These data suggest that, during COD, the bovine ovary is under high sympathetic nerve activity that in addition to an increased
response to hCG in cortisol secretion could participate in COD development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Biomed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Sympathetic Nerve Activity
dc.subject
Cystic Ovarian Disease
dc.subject
Bovine
dc.subject.classification
Otras Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Sympathetic nerve activity in normal and cystic follicles from isolated bovine ovary: local effect of beta-adrenergic stimulation on steroid secretion
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-22T15:20:06Z
dc.identifier.eissn
1477-7827
dc.journal.volume
9
dc.journal.number
66
dc.journal.pagination
1-8
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Paredes, Alfonso H.. Universidad de Chile. Faculty of Chemistry and Pharmaceutical Sciences. Department of Biochemistry and Molecular Biology. Laboratory of Neurobiochemistry; Chile
dc.description.fil
Fil: Salvetti, Natalia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Diaz, Ariel E.. Universidad de Chile. Faculty of Chemistry and Pharmaceutical Sciences. Department of Biochemistry and Molecular Biology. Laboratory of Neurobiochemistry; Chile
dc.description.fil
Fil: Dallard, Bibiana Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Ciencias Veterinarias del Litoral; Argentina; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Lara, Hernán H.. Universidad de Chile. Faculty of Chemistry and Pharmaceutical Sciences. Department of Biochemistry and Molecular Biology. Laboratory of Neurobiochemistry; Chile
dc.journal.title
Reproductive Biology And Endocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org//10.1186/1477-7827-9-66
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://rbej.biomedcentral.com/articles/10.1186/1477-7827-9-66
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