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Artículo

Autoantibodies as biomarkers for interstitial lung disease in idiopathic inflammatory myositis and systemic sclerosis: The case of anti-eIF2B antibodies

Ceribelli, Angela; Isailovic, Natasa; De Santis, Maria; Gorlino, Carolina VirginiaIcon ; Satoh, Minoru; Selmi, Carlo
Fecha de publicación: 01/2020
Editorial: Elsevier
Revista: Journal of Translational Autoimmunity
ISSN: 2589-9090
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Reumatología

Resumen

Objectives: Serum autoantibodies are pivotal for the early detection of systemic autoimmune rheumatic diseases such as Systemic Sclerosis (SSc) and Poly/Dermatomyositis (PM/DM), and in some cases are associated with organ complications such as interstitial lung disease (ILD). A paradigmatic example is provided by the autoantibody against the Eukaryotic Initiation Factor 2B (eIF2B) that has been recently detected in SSc. Methods: Sera from 118 patients with SSc, 8 Poly/Dermatomyositis, 2 overlap SSc/Polymyositis, 4 undifferentiated connective tissue disease-UCTD and 3 healthy controls were tested first by indirect immunofluorescence for anti-nuclear antibodies-ANA pattern. Further, we employed prot ein-radioimmunoprecipitation (IP) and IP- Western Blot for the detection and confirmation of anti-eIF2B antibodies. Serum findings were further correlated with the clinical features of patients. Results: We identified 3 SSc cases (2.5%) positive for anti-eIF2B antibodies while this autoantibody was not detected in control sera. Using protein-IP all three patients manifested the 38kD protein which is the antigenic target of anti-eIF2B antibodies, and this was associated with a cytoplasmic pattern at indirect immunofluorescence. The presence of anti-eIF2B was associated with ILD and a diffuse SSc variant, in one case in association with anti-Scl70/topoI. Conclusions: Our data confirm that a small subgroup (2.5%) of patients with SSc have detectable anti-eIF2B with cytoplasmic-positive staining at immunofluorescence and this reactivity is associated with ILD.
Palabras clave: AUTOIMMUNITY , DERMATOMYOSITIS , INTERSTITIAL LUNG DISEASE , POLYMYOSITIS , SCLERODERMA
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/145010
URL: https://linkinghub.elsevier.com/retrieve/pii/S2589909020300162
DOI: http://dx.doi.org/10.1016/j.jtauto.2020.100049
Colecciones
Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Ceribelli, Angela; Isailovic, Natasa; De Santis, Maria; Gorlino, Carolina Virginia; Satoh, Minoru; et al.; Autoantibodies as biomarkers for interstitial lung disease in idiopathic inflammatory myositis and systemic sclerosis: The case of anti-eIF2B antibodies; Elsevier; Journal of Translational Autoimmunity; 3; 1-2020; 1-5
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