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dc.contributor.author
Mauro, Laura Valeria
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Grossoni, Valeria C.
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Urtreger, Alejandro Jorge
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Yang, Chengfen
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Colombo, Lucas Luis
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Morandi, Ana
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Pallota, María G.
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Kazanietz, Marcelo G.
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Bal, Elisa Dora
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Puricelli, Lydia Ines
dc.date.available
2017-03-29T23:39:57Z
dc.date.issued
2010-01
dc.identifier.citation
Mauro, Laura Valeria; Grossoni, Valeria C.; Urtreger, Alejandro Jorge; Yang, Chengfen; Colombo, Lucas Luis; et al.; PKC delta (PKCδ) promotes tumoral progression of human ductal pancreatic cancer; Lippincott Williams; Pancreas; 39; 1; 1-2010; e31-41
dc.identifier.issn
0885-3177
dc.identifier.uri
http://hdl.handle.net/11336/14494
dc.description.abstract
OBJECTIVE: Our objective was to study the role of protein kinase C delta (PKCdelta) in the progression of human pancreatic carcinoma. METHODS: Protein kinase C delta expression in human ductal carcinoma (n = 22) was studied by immunohistochemistry. We analyzed the effect of PKCdelta overexpression on in vivo and in vitro properties of human ductal carcinoma cell line PANC1. RESULTS: Human ductal carcinomas showed PKCdelta overexpression compared with normal counterparts. In addition, in vitro PKCdelta-PANC1 cells showed increased anchorage-independent growth and higher resistance to serum starvation and to treatment with cytotoxic drugs. Using pharmacological inhibitors, we determined that phosphatidylinositol-3-kinase and extracellular receptor kinase pathways were involved in the proliferation of PKCdelta-PANC1. Interestingly, PKCdelta-PANC1 cells showed a less in vitro invasive ability and an impairment in their ability to migrate and to secrete the proteolytic enzyme matrix metalloproteinase-2. In vivo experiments indicated that PKCdelta-PANC1 cells were more tumorigenic, as they developed tumors with a significantly lower latency and a higher growth rate with respect to the tumors generated with control cells. Besides, only PKCdelta-PANC1 cells developed lung metastasis. CONCLUSION: Our results showed that the overexpression of PKCdelta in PANC1 cells induced a more malignant phenotype in vivo, probably through the modulation of cell proliferation and survival, involving phosphatidylinositol-3-kinase and extracellular receptor kinase signaling pathways.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Human Pancreatic Adenocarcinoma
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Pkcδ
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Invasion
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Pi3k/Akt
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Erk
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Otros Tópicos Biológicos
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
PKC delta (PKCδ) promotes tumoral progression of human ductal pancreatic cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-21T20:12:54Z
dc.journal.volume
39
dc.journal.number
1
dc.journal.pagination
e31-41
dc.journal.pais
Estados Unidos
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Filadelfia
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Fil: Mauro, Laura Valeria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Grossoni, Valeria C.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina
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Fil: Urtreger, Alejandro Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Yang, Chengfen. Michigan State University; Estados Unidos
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Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Morandi, Ana. Hospital Italiano de Buenos Aires; Argentina
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Fil: Pallota, María G.. Hospital Italiano de Buenos Aires; Argentina
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Fil: Kazanietz, Marcelo G.. State University Of Pennsylvania; Estados Unidos
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Fil: Bal, Elisa Dora. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Puricelli, Lydia Ines. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Pancreas
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/pancreasjournal/pages/articleviewer.aspx?year=2010&issue=01000&article=00035&type=abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/MPA.0b013e3181bce796
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