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dc.contributor.author
Overeem, Nico J.
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Hamming, P. H. Erik
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Grant, Oliver C.
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Di Iorio, Daniele
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Tieke, Malte
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Bertolino, María Candelaria
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dc.contributor.author
Li, Zeshi
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Vos, Gaël
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de Vries, Robert P.
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Woods, Robert J.
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Tito, Nicholas B.
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Boons, Geert-Jan P. H.
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van der Vries, Erhard
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Huskens, Jurriaan
dc.date.available
2021-10-19T23:26:07Z
dc.date.issued
2020-11
dc.identifier.citation
Overeem, Nico J.; Hamming, P. H. Erik; Grant, Oliver C.; Di Iorio, Daniele; Tieke, Malte; et al.; Hierarchical Multivalent Effects Control Influenza Host Specificity; American Chemical Society; ACS Central Science; 6; 12; 11-2020; 1-8
dc.identifier.issn
2374-7943
dc.identifier.uri
http://hdl.handle.net/11336/144365
dc.description.abstract
Understanding how emerging influenza viruses recognize host cells is critical in evaluating their zoonotic potential, pathogenicity, and transmissibility between humans. The surface of the influenza virus is covered with hemagglutinin (HA) proteins that can form multiple interactions with sialic acid-terminated glycans on the host cell surface. This multivalent binding affects the selectivity of the virus in ways that cannot be predicted from the individual receptor-ligand interactions alone. Here, we show that the intrinsic structural and energetic differences between the interactions of avian- or human-type receptors with influenza HA translate from individual site affinity and orientation through receptor length and density on the surface into virus avidity and specificity. We introduce a method to measure virus avidity using receptor density gradients. We found that influenza viruses attached stably to a surface at receptor densities that correspond to a minimum number of approximately 8 HA-glycan interactions, but more interactions were required if the receptors were short and human-type. Thus, the avidity and specificity of influenza viruses for a host cell depend not on the sialic acid linkage alone but on a combination of linkage and the length and density of receptors on the cell surface. Our findings suggest that threshold receptor densities play a key role in virus tropism, which is a predicting factor for both their virulence and zoonotic potential.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Viruses
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Chemical specificity
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Carbohydrates
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Receptors
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Biofísica
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Hierarchical Multivalent Effects Control Influenza Host Specificity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T16:41:47Z
dc.identifier.eissn
2374-7951
dc.journal.volume
6
dc.journal.number
12
dc.journal.pagination
1-8
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington, D. C.
dc.description.fil
Fil: Overeem, Nico J.. University of Twente; Países Bajos
dc.description.fil
Fil: Hamming, P. H. Erik. University of Twente; Países Bajos
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Fil: Grant, Oliver C.. University of Georgia; Estados Unidos
dc.description.fil
Fil: Di Iorio, Daniele. University of Twente; Países Bajos
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Fil: Tieke, Malte. Utrecht University; Países Bajos
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Fil: Bertolino, María Candelaria. University of Twente; Países Bajos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
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Fil: Li, Zeshi. Utrecht University; Países Bajos
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Fil: Vos, Gaël. Utrecht University; Países Bajos
dc.description.fil
Fil: de Vries, Robert P.. Utrecht University; Países Bajos
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Fil: Woods, Robert J.. University of Georgia; Estados Unidos
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Fil: Tito, Nicholas B.. Electric Ant Laboratory; Países Bajos
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Fil: Boons, Geert-Jan P. H.. Utrecht University; Países Bajos
dc.description.fil
Fil: van der Vries, Erhard. Utrecht University; Países Bajos
dc.description.fil
Fil: Huskens, Jurriaan. University of Twente; Países Bajos
dc.journal.title
ACS Central Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acscentsci.0c01175
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acscentsci.0c01175
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