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dc.contributor.author
Martini, Claudia Noemí
dc.contributor.author
Sosa, Fernando Nicolás
dc.contributor.author
Fuchs, Julio Silvio
dc.contributor.author
Vila, María del Carmen
dc.date.available
2021-10-15T18:59:11Z
dc.date.issued
2020-04
dc.identifier.citation
Martini, Claudia Noemí; Sosa, Fernando Nicolás; Fuchs, Julio Silvio; Vila, María del Carmen; Effect of lead on proliferation, oxidative stress and genotoxic damage of 3T3-L1 fibroblasts; Oxford University Press; Toxicology Research; 9; 3; 4-2020; 158-163
dc.identifier.uri
http://hdl.handle.net/11336/143932
dc.description.abstract
Lead (Pb) is an environmental and industrial contaminant that still represents a public health problem. In this paper, we investigated the effect of Pb on proliferation, lipid peroxidation and the number of micronucleated cells in exponentially growing 3T3-L1 fibroblasts, a cell line previously used to evaluate different environmental contaminants. We found that Pb (10 μM or higher) was able to inhibit proliferation of exponentially growing cells after 24-h treatment, which was evaluated by the MTT assay and cell counting in Neubauer chamber, but cell survival was not affected according to the trypan blue exclusion assay. On the other hand, Pb was able to increase lipid peroxidation and the number of micronucleated cells, which are indicative of oxidative stress and genotoxic damage respectively. We also found that removal of Pb after 24-h treatment allowed cells to recover proliferation. Our results indicate that Pb was able to induce oxidative stress and genotoxicity in this cell line under standardized conditions, which supports the involvement of Pb in similar effects observed in human exposed to this heavy metal. In addition, Pb inhibits proliferation of exponentially growing fibroblasts but cells resume proliferation after removal of this metal, which suggests that it is important to move away Pb-exposed individuals from the source of contamination.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
3T3-L1 FIBROBLASTS
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LEAD
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LIPID PEROXIDATION
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MICRONUCLEATED CELLS
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PROLIFERATION
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Effect of lead on proliferation, oxidative stress and genotoxic damage of 3T3-L1 fibroblasts
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T18:56:39Z
dc.identifier.eissn
2045-4538
dc.journal.volume
9
dc.journal.number
3
dc.journal.pagination
158-163
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Martini, Claudia Noemí. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Sosa, Fernando Nicolás. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fuchs, Julio Silvio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Vila, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.journal.title
Toxicology Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/toxres/advance-article/doi/10.1093/toxres/tfaa018/5826013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/toxres/tfaa018
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