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dc.contributor.author
Molina, Rocío Daniela Inés  
dc.contributor.author
Campos Silva, Rodrigo  
dc.contributor.author
Díaz, Myriam Anabel  
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Macedo, Alexandre José  
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Blázquez, María Amparo  
dc.contributor.author
Alberto, Maria Rosa  
dc.contributor.author
Arena, Mario Eduardo  
dc.date.available
2021-10-12T20:35:22Z  
dc.date.issued
2020-12  
dc.identifier.citation
Molina, Rocío Daniela Inés; Campos Silva, Rodrigo; Díaz, Myriam Anabel; Macedo, Alexandre José; Blázquez, María Amparo; et al.; Laurel extracts inhibit quorum sensing, virulence factors and biofilm of foodborne pathogens; Elsevier Science; LWT - Food Science and Technology; 134; 12-2020; 1-9; 109899  
dc.identifier.issn
0023-6438  
dc.identifier.uri
http://hdl.handle.net/11336/143339  
dc.description.abstract
Antimicrobial, antibiofilm, anti-Quorum sensing (QS) and virulence factors inhibitory capacity of different polarity Laurus nobilis extracts against several pathogenic microorganisms were studied. Some extracts exhibited antibiotic effect against Staphylococcus aureus multidrug-resistant strains. However, all extracts (100 µg/mL) inhibited to some extent the biofilm of most bacteria tested (until 40% for Gram-negative and 76% for Gram-positive). Hexane (HE) and chloroform extract (CE) were potent inhibitors of S. aureus biofilm and the microscopies further confirmed an important reduction in adherent cells. Polystyrene surfaces coated with these extracts showed a decrease in bacterial adhesion with the resulting inhibition of S. aureus biofilm formation and biofilm activity. Moreover, they also interfere with the coagulase and hemolysin activities of this bacterium. With respect to Gram-negative bacteria, these extracts showed anti-QS activity against Chromobacterium violaceum and inhibited biofilm formation, swarming motility, pyocyanin production, and elastase activity of Pseudomonas aeruginosa. Chemical analysis of HE and CE revealed that the fatty acids were the main compounds, particularly linolenic, oleic and hexadecanoic acids followed by the oxygenated monoterpenes. Non-toxic laurel extracts offer a natural alternative to control contamination and/or spoilage of food, as well as infectious diseases, by attacking the biofilm and the virulence of Gram-positive and Gram-negative bacteria.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
BIOFILM  
dc.subject
ENZYME INHIBITION  
dc.subject
FATTY ACIDS  
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SWARMING  
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PYOCYANIN  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Laurel extracts inhibit quorum sensing, virulence factors and biofilm of foodborne pathogens  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-07-01T13:52:53Z  
dc.journal.volume
134  
dc.journal.pagination
1-9; 109899  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Molina, Rocío Daniela Inés. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina  
dc.description.fil
Fil: Campos Silva, Rodrigo. Universidade Federal do Rio Grande do Sul; Brasil  
dc.description.fil
Fil: Díaz, Myriam Anabel. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina  
dc.description.fil
Fil: Macedo, Alexandre José. Universidade Federal do Rio Grande do Sul; Brasil  
dc.description.fil
Fil: Blázquez, María Amparo. Universidad de Valencia; España  
dc.description.fil
Fil: Alberto, Maria Rosa. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina  
dc.description.fil
Fil: Arena, Mario Eduardo. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina  
dc.journal.title
LWT - Food Science and Technology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.lwt.2020.109899  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0023643820308884