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dc.contributor.author
Johnson, Emma C.
dc.contributor.author
Sanchez Roige, Sandra
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Acion, Laura
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Adams, Mark J.
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Bucholz, Kathleen K.
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Chan, Grace
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Chao, Michael J.
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Chorlian, David B.
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Dick, Danielle M.
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Edenberg, Howard J.
dc.contributor.author
Foroud, Tatiana
dc.contributor.author
Hayward, Caroline
dc.contributor.author
Heron, Jon
dc.contributor.author
Hesselbrock, Victor
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Hickman, Matthew
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Kendler, Kenneth S.
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Kinreich, Sivan
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Kramer, John
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Kuo, Sally I Chun
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Kuperman, Samuel
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Lai, Dongbing
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Mcintosh, Andrew M.
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Meyers, Jacquelyn L.
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Plawecki, Martin H.
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Porjesz, Bernice
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Porteous, David
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Schuckit, Marc A.
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Su, Jinni
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Zang, Yong
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Palmer, Abraham A.
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Agrawal, Arpana
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Clarke, Toni Kim
dc.contributor.author
Edwards, Alexis C.
dc.date.available
2021-10-08T02:38:30Z
dc.date.issued
2020-01
dc.identifier.citation
Johnson, Emma C.; Sanchez Roige, Sandra; Acion, Laura; Adams, Mark J.; Bucholz, Kathleen K.; et al.; Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples; Cambridge University Press; Psychological Medicine; 51; 7; 1-2020; 1147-1156
dc.identifier.issn
0033-2917
dc.identifier.uri
http://hdl.handle.net/11336/143224
dc.description.abstract
Background. Studies suggest that alcohol consumption and alcohol use disorders have distinct genetic backgrounds. Methods. We examined whether polygenic risk scores (PRS) for consumption and problem subscales of the Alcohol Use Disorders Identification Test (AUDIT-C, AUDIT-P) in the UK Biobank (UKB; N = 121 630) correlate with alcohol outcomes in four independent samples: an ascertained cohort, the Collaborative Study on the Genetics of Alcoholism (COGA; N = 6850), and population-based cohorts: Avon Longitudinal Study of Parents and Children (ALSPAC; N = 5911), Generation Scotland (GS; N = 17 461), and an independent subset of UKB (N = 245 947). Regression models and survival analyses tested whether the PRS were associated with the alcohol-related outcomes. Results. In COGA, AUDIT-P PRS was associated with alcohol dependence, AUD symptom count, maximum drinks (R2 = 0.47–0.68%, p = 2.0 × 10−8 –1.0 × 10−10), and increased likelihood of onset of alcohol dependence (hazard ratio = 1.15, p = 4.7 × 10−8 ); AUDIT-C PRS was not an independent predictor of any phenotype. In ALSPAC, the AUDIT-C PRS was associated with alcohol dependence (R2 = 0.96%, p = 4.8 × 10−6 ). In GS, AUDIT-C PRS was a better predictor of weekly alcohol use (R2 = 0.27%, p = 5.5 × 10−11), while AUDIT-P PRS was more associated with problem drinking (R2 = 0.40%, p = 9.0 × 10−7 ). Lastly, AUDIT-P PRS was associated with ICD-based alcohol-related disorders in the UKB subset (R2 = 0.18%, p < 2.0 × 10−16). Conclusions. AUDIT-P PRS was associated with a range of alcohol-related phenotypes across population-based and ascertained cohorts, while AUDIT-C PRS showed less utility in the ascertained cohort. We show that AUDIT-P is genetically correlated with both use and misuse and demonstrate the influence of ascertainment schemes on PRS analyses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALCOHOL CONSUMPTION
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ALCOHOL DEPENDENCE
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ALCOHOL USE DISORDER
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AUDIT
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GENETICS
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GWAS
dc.subject
POLYGENIC RISK SCORE
dc.subject.classification
Drogadicción
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T18:28:11Z
dc.journal.volume
51
dc.journal.number
7
dc.journal.pagination
1147-1156
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Johnson, Emma C.. Washington State University; Estados Unidos
dc.description.fil
Fil: Sanchez Roige, Sandra. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Acion, Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Iowa; Estados Unidos
dc.description.fil
Fil: Adams, Mark J.. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Bucholz, Kathleen K.. Washington State University; Estados Unidos
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Fil: Chan, Grace. University of Connecticut; Estados Unidos
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Fil: Chao, Michael J.. Icahn School Of Medicine At Mount Sinai; ; Estados Unidos
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Fil: Chorlian, David B.. Suny Downstate Health Sciences University; ; Estados Unidos
dc.description.fil
Fil: Dick, Danielle M.. Virginia Commonwealth University; Estados Unidos
dc.description.fil
Fil: Edenberg, Howard J.. Indiana University; Estados Unidos
dc.description.fil
Fil: Foroud, Tatiana. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Hayward, Caroline. Virginia Commonwealth University School of Medicine; Estados Unidos
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Fil: Heron, Jon. University Of Bristol; Reino Unido
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Fil: Hesselbrock, Victor. University of Connecticut; Estados Unidos
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Fil: Hickman, Matthew. University Of Bristol; Reino Unido
dc.description.fil
Fil: Kendler, Kenneth S.. Virginia Commonwealth University School of Medicine; Estados Unidos
dc.description.fil
Fil: Kinreich, Sivan. Suny Downstate Medical Center; Estados Unidos
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Fil: Kramer, John. University of Iowa; Estados Unidos
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Fil: Kuo, Sally I Chun. Virginia Commonwealth University School of Medicine; Estados Unidos
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Fil: Kuperman, Samuel. University of Iowa; Estados Unidos
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Fil: Lai, Dongbing. Indiana University; Estados Unidos
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Fil: Mcintosh, Andrew M.. University of Edinburgh; Reino Unido
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Fil: Meyers, Jacquelyn L.. Suny Downstate Medical Center; Estados Unidos
dc.description.fil
Fil: Plawecki, Martin H.. Indiana University; Estados Unidos
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Fil: Porjesz, Bernice. Suny Downstate Medical Center; Estados Unidos
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Fil: Porteous, David. University of Edinburgh; Reino Unido
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Fil: Schuckit, Marc A.. University of California at San Diego; Estados Unidos
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Fil: Su, Jinni. Arizona State University; Estados Unidos
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Fil: Zang, Yong. Indiana University; Estados Unidos
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Fil: Palmer, Abraham A.. University of California at San Diego; Estados Unidos
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Fil: Agrawal, Arpana. University of Washington; Estados Unidos
dc.description.fil
Fil: Clarke, Toni Kim. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Edwards, Alexis C.. Virginia Commonwealth University School of Medicine; Argentina
dc.journal.title
Psychological Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/product/identifier/S0033291719004045/type/journal_article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S0033291719004045
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