Artículo
Lanostanoid triterpenes from the fungus Rigidoporus microporus
Rincón, Yuliet A.; Siless, Gastón Ezequiel
; Amado, Lucia Daniela; Dansey, Maria Virginia
; Grassi, Emanuel Marcelo
; Schenone, Nahuel Francisco
; Cabrera, Gabriela Myriam
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Fecha de publicación:
04/2020
Editorial:
Taylor & Francis Ltd
Revista:
Natural Product Research
ISSN:
1478-6419
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Five new lanostanoid triterpenes were isolated from the extract of R. microporus. Three of the metabolites (1–3) present a D8,9 skeleton with an uncommon keto functionality at C–1. Another compound (4) has an unprecedented rearranged skeleton in which methyl-19 was transposed to C–1, with conjugated double bonds at D1–10 and D8–9 . All of the compounds have hydroxylated or furane-cyclized side-chains. The structures were elucidated by spectroscopic methods, and the absolute configuration of the hydroxyl-bearing carbon in the side chain of compound 5 was established in silico. The metabolites were evaluated for their antifungal activity and the bioactivity as agonist/antagonists of the liver X receptors (LXRs). Compound 4 presents antifungal activity and compounds 3 and 5 are the agonists of LXRs.
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Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Rincón, Yuliet A.; Siless, Gastón Ezequiel; Amado, Lucia Daniela; Dansey, Maria Virginia; Grassi, Emanuel Marcelo; et al.; Lanostanoid triterpenes from the fungus Rigidoporus microporus; Taylor & Francis Ltd; Natural Product Research; 2020; 4-2020; 1-11
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