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dc.contributor.author
Numberger, John I.
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Ziyi Yang
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Zang, Yong
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Acion, Laura
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Bierut, Laura
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Bucholz, Kathleen
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Chan, Grace
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Dick, Danielle M.
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Edenberg, Howard J.
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Krame, John
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Kuperman, Samuel
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Rice, John P.
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Schuckit, Marc
dc.date.available
2021-10-07T18:41:27Z
dc.date.issued
2019-10
dc.identifier.citation
Numberger, John I.; Ziyi Yang; Zang, Yong; Acion, Laura; Bierut, Laura; et al.; Development of Alcohol Use Disorder as a Function of Age, Severity, and Comorbidity with Externalizing and Internalizing Disorders in a Young Adult Cohort; Hapres; Journal of Psychiatry and Brain Science; 4; e190016.; 10-2019; 1-17
dc.identifier.issn
2398-385X
dc.identifier.uri
http://hdl.handle.net/11336/143189
dc.description.abstract
Background:As part of the ongoing Collaborative Study of the Genetics of Alcoholism, we performed a longitudinal study of a high risk cohort of adolescents/young adults from families with a proband with an alcohol use disorder, along with a comparison group of age-matched controls. The intent was to compare the development of alcohol problems in subjects at risk with and without comorbid externalizing and internalizing psychiatric disorders.Methods:Subjects (N = 3286) were assessed with a structured psychiatric interview at 2 year intervals over 10 years (2004?2017). The age range at baseline was 12?21.Results:Subjects with externalizing disorders (with or without accompanying internalizing disorders) were at increased risk for the onset of an alcohol use disorder during the observation period. Subjects with internalizing disorders were at greater risk than those without comorbid disorders for onset of a moderate or severe alcohol use disorder. The statistical effect of comorbid disorders was greater in subjects with more severe alcohol use disorders. The developmental trajectory of drinking milestones and alcohol use disorders was also accelerated in those with more severe disorders.Conclusions:These results may be useful for counseling of subjects at risk who present for clinical care, especially those subjects manifesting externalizing and internalizing disorders in the context of a positive family history of an alcohol use disorder. We confirm and extend findings that drinking problems in subjects at greatest risk will begin in early adolescence.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hapres
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AUD
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HIGH RISK STUDIES
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FAMILY STUDIES
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INTERNALIZING
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Drogadicción
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Development of Alcohol Use Disorder as a Function of Age, Severity, and Comorbidity with Externalizing and Internalizing Disorders in a Young Adult Cohort
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-12-09T20:15:35Z
dc.journal.volume
4
dc.journal.number
e190016.
dc.journal.pagination
1-17
dc.journal.pais
Reino Unido
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dc.journal.ciudad
London
dc.description.fil
Fil: Numberger, John I.. Indiana University; Estados Unidos
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Fil: Ziyi Yang. Indiana University; Estados Unidos
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Fil: Zang, Yong. Indiana University; Estados Unidos
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Fil: Acion, Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Calculo. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Calculo; Argentina
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Fil: Bierut, Laura. University of Washington; Estados Unidos
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Fil: Bucholz, Kathleen. University of Washington; Estados Unidos
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Fil: Chan, Grace. University of Connecticut School of Medicine; Estados Unidos
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Fil: Dick, Danielle M.. Virginia Commonwealth University; Estados Unidos
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Fil: Edenberg, Howard J.. Indiana University; Estados Unidos
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Fil: Krame, John. University of Iowa Carver College of Medicine; Estados Unidos
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Fil: Kuperman, Samuel. University of Iowa Carver College of Medicine; Estados Unidos
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Fil: Rice, John P.. Washington University in St. Louis School of Medicine; Estados Unidos
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Fil: Schuckit, Marc. University of California San Diego School of Medicine; Estados Unidos
dc.journal.title
Journal of Psychiatry and Brain Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919651/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.20900/jpbs.20190016
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