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dc.contributor.author
Jorge, Ricardo E.
dc.contributor.author
Li, Ruosha
dc.contributor.author
Liu, Xiangyu
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McGavin, Jill K.
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Shorter, Daryl I.
dc.contributor.author
Acion, Laura
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dc.contributor.author
Arndt, Stephan
dc.date.available
2021-10-07T18:28:02Z
dc.date.issued
2019-10
dc.identifier.citation
Jorge, Ricardo E.; Li, Ruosha; Liu, Xiangyu; McGavin, Jill K.; Shorter, Daryl I.; et al.; Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury; American Neuropsychiatric Association; Journal of Neuropsychiatry and Clinical Neurosciences; 31; 4; 10-2019; 319-327
dc.identifier.issn
0895-0172
dc.identifier.uri
http://hdl.handle.net/11336/143188
dc.description.abstract
Objective: The authors examined the efficacy of valproate to reduce relapse to heavy drinking among veterans with alcohol use disorder (AUD) and neuropsychiatric comorbidities and whether antecedent traumatic brain injury (TBI) or posttraumatic stress disorder (PTSD) affected treatment response. Methods: Participants were male veterans 18–60 years old with an AUD and no other substance use besides nicotine or cannabis. Sixty-two patients were randomly assigned to receive either valproate or naltrexone. Participants were evaluated at baseline and followed weekly for 24 weeks. All participants received standardized psychosocial interventions as well as treatment for coexistent psychiatric conditions. Results: During the follow-up period, nine study subjects in the naltrexone group and 14 in the valproate group relapsed to heavy drinking, but the difference did not reach statistical significance. Participants with a history of moderate to severe TBI were more likely to relapse to heavy drinking compared with those with no TBI (hazard ratio=4.834, 95% CI=1.103–21.194, p=0.033). PTSD status did not significantly affect outcome. Conclusions: Intensive outpatient programs are efficacious alternatives to treat AUD in veterans, although the role of pharmacological treatment is not completely elucidated. Glutamatergic agents appear to be less effective than opiate antagonists to prevent relapse to heavy drinking and to increase cumulative abstinence. Future studies should examine novel pharmacological and nonpharmacological options.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Neuropsychiatric Association
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Traumatic Brain Injury
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AUD
dc.subject
Veterans
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-12-09T20:17:17Z
dc.journal.volume
31
dc.journal.number
4
dc.journal.pagination
319-327
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Jorge, Ricardo E.. Baylor College of Medicine;
dc.description.fil
Fil: Li, Ruosha. Baylor College of Medicine;
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Fil: Liu, Xiangyu. Baylor College of Medicine;
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Fil: McGavin, Jill K.. Baylor College of Medicine;
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Fil: Shorter, Daryl I.. Baylor College of Medicine;
dc.description.fil
Fil: Acion, Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Calculo. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Calculo; Argentina
dc.description.fil
Fil: Arndt, Stephan. University of Iowa; Estados Unidos
dc.journal.title
Journal of Neuropsychiatry and Clinical Neurosciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://psychiatryonline.org/doi/10.1176/appi.neuropsych.18110250
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1176/appi.neuropsych.18110250
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