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dc.contributor.author
Berger, Sandy  
dc.contributor.author
Boettger, Michael Karl  
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Tancer, Manuel  
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Guinjoan, Salvador Martín  
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Yeragani, Vikram K.  
dc.contributor.author
Bär, Karl-Jürgen  
dc.date.available
2017-03-27T21:03:37Z  
dc.date.issued
2010-03  
dc.identifier.citation
Berger, Sandy; Boettger, Michael Karl; Tancer, Manuel; Guinjoan, Salvador Martín; Yeragani, Vikram K.; et al.; Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia; Elsevier Inc; Progress of Neuro-psychopharmacology and Biological Psychiatry; 34; 2; 3-2010; 406-411  
dc.identifier.issn
0278-5846  
dc.identifier.uri
http://hdl.handle.net/11336/14304  
dc.description.abstract
Previous studies have observed reduced vagal modulation in patients with acute schizophrenia and their first-degree relatives, thus suggesting a genetic predisposition. To investigate vagal modulation, we analyzed the coupling between heart rate and breathing as a putative measure of central autonomic function in 19 patients, 19 of their relatives and 19 matched control subjects. The interaction of heart rate and breathing was investigated in all groups applying the non-linear parameter cross-ApEn, indicating the asynchrony between both time series. In addition, measures of the time and frequency domain of heart rate variability (HRV) were obtained. The main finding of our study is a significantly increased cross-ApEn value, indicating reduced central vagal modulation both in relatives and patients suffering from schizophrenia. Non-linear measures of HRV proved to more sensitively differentiate relatives from control subjects. Furthermore, we observed a correlation between psychopathology and breathing, indicating that positive symptoms are associated with a higher degree of regularity in the breathing pattern. Our results suggest that autonomic dysfunction previously described for patients suffering from schizophrenia is also present in first-degree relatives. This might relate to changes of brainstem activity in patients and relatives, and a common genetic background in patients and their family members can be assumed.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Autonomic Function  
dc.subject
Bbreathing Rate  
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Ccardio-Respiratory Coupling  
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Schizophrenia  
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Vagal Tone  
dc.subject.classification
Otras Ciencias de la Salud  
dc.subject.classification
Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-03-21T20:11:42Z  
dc.journal.volume
34  
dc.journal.number
2  
dc.journal.pagination
406-411  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Berger, Sandy. Universitat Jena; Alemania  
dc.description.fil
Fil: Boettger, Michael Karl. Universitat Jena; Alemania  
dc.description.fil
Fil: Tancer, Manuel. Wayne State University School of Medicine; Estados Unidos  
dc.description.fil
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Yeragani, Vikram K.. Wayne State University School of Medicine; Estados Unidos. University of Alberta; Canadá  
dc.description.fil
Fil: Bär, Karl-Jürgen . Universitat Jena; Alemania. Ruhr-universität Bochum; Alemania  
dc.journal.title
Progress of Neuro-psychopharmacology and Biological Psychiatry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584610000175  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pnpbp.2010.01.009