Artículo

In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells

Balsa, Lucia MarianaIcon ; Quispe Castillo, Patricia AraceliIcon ; Baran, Enrique JoséIcon ; Lavecchia, Martín JoséIcon ; Leon, Ignacio EstebanIcon
Fecha de publicación: 14/10/2020
Editorial: Royal Society of Chemistry
Revista: Metallomics
ISSN: 1756-5901
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The study of novel mechanisms of action of vanadium compounds is critical to elucidating the role and importance of these kinds of compounds as antitumor and antimetastatic agents. This work deals with in silico and in vitro studies of one clioquinol oxidovanadium(iv) complex [VO(clioquinol)2], VO(CQ)2, and its regulation of FAK. In particular, we focus on elucidating the relationship of the FAK inhibition, MMP activity and antimetastatic effects of the complex in human bone cancer cells.
Palabras clave: Vanadium , VOCQ2 , FAK , Antitumor Effect
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/142954
DOI: http://dx.doi.org/10.1039/D0MT00176G
URL: https://pubs.rsc.org/en/Content/ArticleLanding/2020/MT/D0MT00176G
Colecciones
Articulos(CEQUINOR)
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Citación
Balsa, Lucia Mariana; Quispe Castillo, Patricia Araceli; Baran, Enrique José; Lavecchia, Martín José; Leon, Ignacio Esteban; In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells; Royal Society of Chemistry; Metallomics; 12; 12; 14-10-2020; 1931-1940
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