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dc.contributor.author
Picco, Soledad
dc.contributor.author
Bavassi, Mariana Luz
dc.contributor.author
Fernández, Rodrigo Sebastián
dc.contributor.author
Pedreira, Maria Eugenia
dc.date.available
2021-10-06T18:21:54Z
dc.date.issued
2020-01
dc.identifier.citation
Picco, Soledad; Bavassi, Mariana Luz; Fernández, Rodrigo Sebastián; Pedreira, Maria Eugenia; A working memory intervention weakens the reconsolidation of a threat memory and its biases processing towards threat; Biorxiv; Biorxiv; 1-2020; 1-31
dc.identifier.issn
0090-502X
dc.identifier.uri
http://hdl.handle.net/11336/142923
dc.description.abstract
BACKGROUND Threat-conditioning (TC) memory plays a central role in anxiety disorders, but not in a simple way. This memory impacts on complex cognitive systems by modifying behavioral responses with a bias to fearful stimuli and overestimating potential threats. In this study we proposed a global approach analyzing the scope of disrupting TC memory reconsolidation in the implicit memory, the declarative contingency and the cognitive biases. METHODS Day 1: Subjects were trained on TC. Day 2: after Threat-memory reactivation, one group performed a high demanding working memory task (HWM) and the other a low demanding working memory task (LWM). The last group, only performed the HWM task. Day 3: TC memory was tested by an extinction session followed by reinstatement. Finally, all subjects completed tasks targeting stimuli representation, valuation and attentional bias towards threat. RESULTS Disrupting reconsolidation of TC memory with a HWM weakened the implicit memory retention and faded the representation and valuation towards threat but it had no effect on attentional bias. Moreover, we revealed that subjects’ performance during the working memory task was specifically associated in TC memory retention. CONCLUSIONS Our findings reveal a strong impairment of the threat-memory restabilization and associated emotional biases. This may result from the competition between defensive survival and central-executive control networks. Our results fits with Experimental Psychopathology approach, disentangling the relation between the implicit memory, cognitive, valenced systems and the possibility to weaken both the threatening memory and the systems associated with the maintenance of anxiety profile.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Biorxiv
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
RECONSOLIDATION
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MEMORY
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WORKING MEMORY
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ATTENTIONAL BIAS
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
A working memory intervention weakens the reconsolidation of a threat memory and its biases processing towards threat
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T18:40:36Z
dc.journal.pagination
1-31
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Picco, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Bavassi, Mariana Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Fernández, Rodrigo Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Biorxiv
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2020.01.08.898643v1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1101/2020.01.08.898643
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