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dc.contributor.author
Bermudez, Jose Maria
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dc.contributor.author
Grau, Ricardo Jose Antonio
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dc.date.available
2017-03-27T19:01:59Z
dc.date.issued
2011-09
dc.identifier.citation
Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation; International Research Journals Publishing House; International Research Journal of Pharmacy and Pharmacology; 1; 6; 9-2011; 109-118
dc.identifier.issn
2251-0176
dc.identifier.uri
http://hdl.handle.net/11336/14288
dc.description.abstract
The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
International Research Journals Publishing House
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Drug Delivery
dc.subject
In Situ Forming Gel
dc.subject
Injectable Depot
dc.subject
Poloxamer
dc.subject
Veterinary Use
dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-22T15:08:30Z
dc.journal.volume
1
dc.journal.number
6
dc.journal.pagination
109-118
dc.journal.pais
Nigeria
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dc.journal.ciudad
Sapele
dc.description.fil
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina. Universidad Nacional de Salta; Argentina
dc.description.fil
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
dc.journal.title
International Research Journal of Pharmacy and Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.interesjournals.org/irjpp/september-2011-vol-1-issue-6/thermosensitive-poloxamer-based-injectables-as-controlled-drug-release-platformsfor-veterinary-use-development-and-in-vitro-evaluation
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