Pharmacotherapy with 17β-estradiol and progesterone prevents development of mouse experimental autoimmune encephalomyelitis

Pregnant women with multiple sclerosis (MS) show disease remission in the third trimester concomitant with high circulating levels of sex steroids. Rodent experimental autoimmune encephalomyelitis (EAE) is an accepted model for MS. Previous studies have shown that monotherapy with estrogens or progesterone exert beneficial effects on EAE. The aim of the present study was to determine if estrogen and progesterone cotherapy of C57BL/6 female mice provided substantial protection from EAE.

Palabras clave: Multiple Sclerosis , Progesterone , Estradiol , Experimenta Autoimmune Encephalomyelitis , Myelination

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/14286

URL: https://www.degruyter.com/view/j/hmbci.2010.1.issue-1/hmbci.2010.006/hmbci.2010.

DOI: http://doi.org/10.1515/hmbci.2010.006

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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Citación

Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Gierman, Lobke; Lima, Analia Ethel; Roig, Paulina; et al.; Pharmacotherapy with 17β-estradiol and progesterone prevents development of mouse experimental autoimmune encephalomyelitis; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 1; 1; 1-1-2010; 43-51

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