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dc.contributor.author
Alvarez Lorenzo, Carmen
dc.contributor.author
Rey Rico, Ana
dc.contributor.author
Sosnik, Alejandro Dario
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dc.contributor.author
Taboada, Pablo
dc.contributor.author
Concheiro, Ángel
dc.date.available
2017-03-27T15:56:39Z
dc.date.issued
2010-12
dc.identifier.citation
Alvarez Lorenzo, Carmen; Rey Rico, Ana; Sosnik, Alejandro Dario; Taboada, Pablo; Concheiro, Ángel; Poloxamine-based nanomaterials for drug delivery; Frontiers In Bioscience Inc; Frontiers In Bioscience-landmark; E2; 102; 12-2010; 424-440
dc.identifier.issn
1093-9946
dc.identifier.uri
http://hdl.handle.net/11336/14273
dc.description.abstract
Poloxamines (Tetronic) are X-shaped amphiphilic block copolymers formed by four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks bonded to a central ethylenediamine moiety. Such a structure confers multi-responsive behaviour, namely temperature and pH-sensitiveness. At relatively low concentrations but above the critical micellar concentration (CMC), poloxamines generate polymeric micelles. Due to the presence of a hydrophobic core, these nanocarriers are useful in the solubilization and stabilization of poorly water-soluble drugs. Moreover, chemical modification of the micellar core is feasible. These remarkable and unique features, compared to the well-known linear poloxamers, have motivated an increasing interest in the study and application of the branched derivatives in different emerging disciplines. The present review concisely overviews the most important developments comprising the application of poloxamines in drug delivery, mainly as micellar carriers capable of enhancing drug solubility and stability, and also as surface modifiers in the technology of stealth polymeric nanoparticles. Their potential for the administration of drugs by different routes and the improvement of the drug bioavailability and therapeutic effect are discussed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers In Bioscience Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nanotechnology
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Polymeric Micelles
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Drug Encapsulation And Delivery
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Amphiphilic Copolymers
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Drug Solubilization
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Drug Stability
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Peo-Ppo Block Copolymers
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Poloxamines
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Stealth Nanoparticles
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Tetronics
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Review
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Poloxamine-based nanomaterials for drug delivery
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-21T20:12:41Z
dc.identifier.eissn
1093-4715
dc.journal.volume
E2
dc.journal.number
102
dc.journal.pagination
424-440
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Irvine
dc.description.fil
Fil: Alvarez Lorenzo, Carmen. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Rey Rico, Ana. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Taboada, Pablo. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Concheiro, Ángel. Universidad de Santiago de Compostela; España
dc.journal.title
Frontiers In Bioscience-landmark
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.bioscience.org/2010/v2e/af/102/fulltext.php?bframe=2.htm
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