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dc.contributor.author
Danesi, Emmaría
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dc.contributor.author
Fabbro, Diana Lucrecia
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dc.contributor.author
Segura, Elsa Leonor
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dc.contributor.author
Sosa-Estani, Sergio Alejandro
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dc.date.available
2021-10-05T13:35:39Z
dc.date.issued
2020-03
dc.identifier.citation
Danesi, Emmaría; Fabbro, Diana Lucrecia; Segura, Elsa Leonor; Sosa-Estani, Sergio Alejandro; Higher congenital transmission rate of Trypanosoma cruzi associated with family history of congenital transmission; Sociedade Brasileira de Medicina Tropical; Revista Da Sociedade Brasileira de Medicina Tropical; 53; 3-2020; 1-7
dc.identifier.issn
0037-8682
dc.identifier.uri
http://hdl.handle.net/11336/142656
dc.description.abstract
Introduction: Congenital transmission (CT) of Trypanosoma cruzi has led to globalization of Chagas disease and its growing relevance as a public health problem. Although the occurrence of CT has been associated with several factors, its mechanisms are still unknown. This study aimed to analyze the geographical and familiar variables of mothers and their association with CT of Chagas disease in a population living in non-endemic areas of Argentina for the last decades. Methods: We developed a retrospective cohort study in a sample of 2120 mother-child pairs who attended three reference centers in the cities of Buenos Aires, Santa Fe, and Salta between 2002 and 2015. Results: The highest CT rates were observed in children born to Argentinean mothers (10.7%) and in children born to mothers from Buenos Aires (11.7%). Considering the areas of origin of the mothers, those from areas of null-low risk for vector-borne infection had higher CT rates than those from areas of medium-high risk (11.1% vs 8.2%). We also observed a significant intra-familiar “cluster effect,” with CT rates of 35.9% in children with an infected sibling, compared to 8.2% in children without infected siblings (RR=4.4 95% CI 2.3-8.4). Conclusions: The associations observed suggest a higher CT rate in children born to mothers who acquired the infection congenitally, with familiar antecedents, and from areas without the presence of vectors. These observations are considered new epidemiological evidence about Chagas disease in a contemporary urban population, which may contribute to the study of CT and may also be an interesting finding for healthcare professionals.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedade Brasileira de Medicina Tropical
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CONGENITAL CHAGAS DISEASE
dc.subject
EPIDEMIOLOGY
dc.subject
FAMILY CLUSTERING
dc.subject
TRYPANOSOMA CRUZI
dc.subject
VERTICAL INFECTION
dc.subject
VERTICAL TRANSMISSION
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Higher congenital transmission rate of Trypanosoma cruzi associated with family history of congenital transmission
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T15:01:23Z
dc.identifier.eissn
1678-9849
dc.journal.volume
53
dc.journal.pagination
1-7
dc.journal.pais
Brasil
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dc.description.fil
Fil: Danesi, Emmaría. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Centro Nacional de Diagnóstico e Investigaciones Endemo-epidémicas; Argentina
dc.description.fil
Fil: Fabbro, Diana Lucrecia. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Segura, Elsa Leonor. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
dc.journal.title
Revista Da Sociedade Brasileira de Medicina Tropical
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100319&tlng=en
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/0037-8682-0560-2019
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