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dc.contributor.author
Rey, Rodolfo Alberto
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dc.date.available
2021-10-05T12:21:48Z
dc.date.issued
2020-04
dc.identifier.citation
Rey, Rodolfo Alberto; Biomarkers of male hypogonadism in childhood and adolescence; De Gruyter; Advances in Laboratory Medicine; 2020; 0024; 4-2020; 1-13
dc.identifier.issn
2628-491X
dc.identifier.uri
http://hdl.handle.net/11336/142631
dc.description.abstract
Objectives: The objective of this review was to characterize the use of biomarkers of male hypogonadism in childhood and adolescence. Contents: The hypothalamic-pituitary-gonadal (HPG) axis is active during fetal life and over the first months of postnatal life. The pituitary gland secretes follicle stimulating hormone (FSH) and luteinizing hormone (LH), whereas the testes induce Leydig cells to produce testosterone and insulin-like factor 3 (INSL), and drive Sertoli cells to secrete anti-Müllerian hormone (AMH) and inhibin B. During childhood, serum levels of gonadotropins, testosterone and insulin-like 3 (INSL3) decline to undetectable levels, whereas levels of AMH and inhibin B remain high. During puberty, the production of gonadotropins, testosterone, and INSL3 is reactivated, inhibin B increases, and AMH decreases as a sign of Sertoli cell maturation. Summary and outlook: Based on our knowledge of the developmental physiology of theHPG axis, these biomarkers can be used in clinical practice to interpret the physiopathology of hypogonadism. Additionally, these markers can have diagnostic value in different forms of hypogonadism that may appear during childhood and adolescence.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
De Gruyter
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
AMBIGUOUS GENITALIA
dc.subject
CRYPTORCHIDISM
dc.subject
GONADAL DYSGENESIS
dc.subject
MICROPENIS
dc.subject.classification
Pediatría
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Biomarkers of male hypogonadism in childhood and adolescence
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-08-20T19:45:15Z
dc.journal.volume
2020
dc.journal.number
0024
dc.journal.pagination
1-13
dc.journal.pais
Alemania
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dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
dc.journal.title
Advances in Laboratory Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/journals/almed/ahead-of-print/article-10.1515-almed-2020-0024/article-10.1515-almed-2020-0024.xml
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/almed-2020-0024
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