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dc.contributor.author
Longo, Gabriel Sebastian  
dc.contributor.other
AlMaadeed, Mariam Al Ali  
dc.contributor.other
Deepalekshmi Ponnamma  
dc.contributor.other
Carignano, Marcelo A.  
dc.date.available
2021-10-05T01:56:33Z  
dc.date.issued
2020  
dc.identifier.citation
Longo, Gabriel Sebastian; An example of theoretical approaches in polymer hydrogels: insights into the behavior of pH-responsive Nanofilms; Elsevier; 2020; 229-256  
dc.identifier.isbn
978-0-12-816808-0  
dc.identifier.uri
http://hdl.handle.net/11336/142586  
dc.description.abstract
Due to their self-regulating behavior, pH-responsive hydrogels are frequently considered in the development of functional biomaterials. A rational approach to designing new biomaterials imposes the need to understate their interaction with protein solutions. On the basis of theoretical work, this chapter describes the adsorption of proteins and peptides to films of cross-linked pH-sensitive polymers. Particular emphasis is placed on the physical chemistry that emerges from the charge regulation properties of hydrogels and proteins. As a result of spatial confinement, the acidic units that compose a polymer network modify their protonation state as well as the composition of the surroundings; the local pH drops inside the hydrogel, increasing protein protonation upon adsorption. Having different amino acid residues that protonate or deprotonate under different conditions supplies proteins with degrees of freedom to modify their net charge and, thus, modulate the electrostatic interactions with a given hydrogel that drive adsorption. Tailoring a polymer network’s chemical composition allows for the separation and localization of specific components from multiprotein solutions using pH.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
pH-RESPONSIVE HYDROGELS  
dc.subject
PROTEIN ADSORPTION  
dc.subject
PROTEIN PROTONATION  
dc.subject
MOLECULAR MODELING  
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica  
dc.subject.classification
Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
An example of theoretical approaches in polymer hydrogels: insights into the behavior of pH-responsive Nanofilms  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2021-09-06T17:27:13Z  
dc.journal.pagination
229-256  
dc.journal.pais
Países Bajos  
dc.description.fil
Fil: Longo, Gabriel Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/B978012816808000007X  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/B978-0-12-816808-0.00007-X  
dc.conicet.paginas
672  
dc.source.titulo
Polymer Science and Innovative Applications:Materials, Techniques, and Future Developments