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dc.contributor.author Fernández Canigia, Liliana
dc.contributor.author Litterio, Mirta
dc.contributor.author Legaria, María C.
dc.contributor.author Castello, Liliana
dc.contributor.author Predari, Silvia C.
dc.contributor.author Di Martino, Ana
dc.contributor.author Rossetti, Adelaida
dc.contributor.author Rollet, Raquel
dc.contributor.author Carloni, Graciela
dc.contributor.author Bianchini, Hebe
dc.contributor.author Cejas, Daniela
dc.contributor.author Radice, Marcela Alejandra
dc.contributor.author Gutkind, Gabriel Osvaldo
dc.contributor.author Anaerobe Surveillance Team
dc.date.available 2017-03-27T14:30:19Z
dc.date.issued 2012-01
dc.identifier.citation Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; et al.; First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 56; 3; 1-2012; 1309-1314
dc.identifier.issn 0066-4804
dc.identifier.uri http://hdl.handle.net/11336/14250
dc.description.abstract The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%.
dc.format application/pdf
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Bacteroides fragilis group
dc.subject Emerging resistance to carbapenems
dc.subject.classification Biología Celular, Microbiología
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-03-20T17:40:46Z
dc.identifier.eissn 1098-6596
dc.journal.volume 56
dc.journal.number 3
dc.journal.pagination 1309-1314
dc.journal.pais Estados Unidos
dc.journal.ciudad Washington
dc.description.fil Fil: Fernández Canigia, Liliana. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Litterio, Mirta. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Legaria, María C.. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Castello, Liliana. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Predari, Silvia C.. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Di Martino, Ana. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Rossetti, Adelaida. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Rollet, Raquel. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Carloni, Graciela. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Bianchini, Hebe. Asociación Argentina de Microbiología; Argentina
dc.description.fil Fil: Cejas, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Anaerobe Surveillance Team.
dc.journal.title Antimicrobial Agents and Chemotherapy
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/56/3/1309.full
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/AAC.05622-11


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)