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dc.contributor.author
Murai, Shin
dc.contributor.author
Stein, Paula
dc.contributor.author
Buffone, Mariano Gabriel
dc.contributor.author
Yamashita, Shigeru
dc.contributor.author
Schultz, Richard M.
dc.date.available
2017-03-27T14:15:39Z
dc.date.issued
2010-05-01
dc.identifier.citation
Murai, Shin; Stein, Paula; Buffone, Mariano Gabriel; Yamashita, Shigeru; Schultz, Richard M.; Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos; Elsevier Inc; Developmental Biology; 341; 1; 1-5-2010; 205-212
dc.identifier.issn
0012-1606
dc.identifier.uri
http://hdl.handle.net/11336/14247
dc.description.abstract
Mouse oocytes acquire the ability to replicate DNA during meiotic maturation, presumably to ensure that DNA replication does not occur precociously between MI and MII and only after fertilization. Acquisition of DNA replication competence requires protein synthesis, but the identity of the proteins required for DNA replication is poorly described. In Xenopus, the only component missing for DNA replication competence is CDC6, which is synthesized from a dormant maternal mRNA recruited during oocyte maturation, and a similar situation also occurs during mouse oocyte maturation. We report that ORC6L is another component required for acquisition of DNA replication competence that is absent in mouse oocytes. The dormant maternal Orc6l mRNA is recruited during maturation via a CPE present in its 3␣ UTR. RNAi-mediated ablation of maternal Orc6l mRNA prevents the maturation-associated increase in ORC6L protein and inhibits DNA replication in 1-cell embryos. These results suggest that mammalian oocytes have more complex mecha- nisms to establish DNA replication competence when compared to their Xenopus counterparts.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Dna Replication
dc.subject
Dormant Maternal Mrna
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Cytoplasmic Poladenylation Element
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Mouse 1-Cell Embryo
dc.subject.classification
Biología Reproductiva
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-23T18:24:30Z
dc.identifier.eissn
1095-564X
dc.journal.volume
341
dc.journal.number
1
dc.journal.pagination
205-212
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Diego
dc.description.fil
Fil: Murai, Shin. State University Of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Stein, Paula. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Yamashita, Shigeru. Toho University. School of Medicine; Japón
dc.description.fil
Fil: Schultz, Richard M.. University of Pennsylvania; Estados Unidos
dc.journal.title
Developmental Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0012160610001351
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ydbio.2010.02.027
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854205/
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