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dc.contributor.author
Fischer, Will
dc.contributor.author
Giorgi, Elena E.
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Chakraborty, Srirupa
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Nguyen, Kien
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Bhattacharya, Tanmoy
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Theiler, James
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Goloboff, Pablo Augusto
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Yoon, Hyejin
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Abfalterer, Werner
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Foley, Brian T.
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Tegally, Houriiyah
dc.contributor.author
San, James Emmanuel
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de Oliveira, Tulio
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Gnanakaran, Sandrasegaram
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Korber, Bette
dc.date.available
2021-10-04T15:21:05Z
dc.date.issued
2021-07
dc.identifier.citation
Fischer, Will; Giorgi, Elena E.; Chakraborty, Srirupa; Nguyen, Kien; Bhattacharya, Tanmoy; et al.; HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens; Cell Press; Cell Host & Microbe; 29; 7; 7-2021; 1093-1110
dc.identifier.issn
1931-3128
dc.identifier.uri
http://hdl.handle.net/11336/142461
dc.description.abstract
Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
EVOLUTION
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GLYCOSYLATION
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HIV-1
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IMMUNE ESCAPE
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INSERTIONS AND DELETIONS
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RECOMBINATION
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SARS-COV-2
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COVID-19
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Biología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-10-04T15:08:09Z
dc.journal.volume
29
dc.journal.number
7
dc.journal.pagination
1093-1110
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New Jersey
dc.description.fil
Fil: Fischer, Will. Los Alamos National Laboratory; Estados Unidos. New Mexico Consortium; México
dc.description.fil
Fil: Giorgi, Elena E.. New Mexico Consortium; México. Los Alamos National Laboratory; Estados Unidos
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Fil: Chakraborty, Srirupa. Center For Nonlinear Studies; Estados Unidos. Los Alamos National Laboratory; Estados Unidos
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Fil: Nguyen, Kien. Los Alamos National Laboratory; Estados Unidos
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Fil: Bhattacharya, Tanmoy. Los Alamos National Laboratory; Estados Unidos
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Fil: Theiler, James. Los Alamos National Laboratory; Estados Unidos
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Fil: Goloboff, Pablo Augusto. American Museum of Natural History; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; Argentina
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Fil: Yoon, Hyejin. Los Alamos National Laboratory; Estados Unidos
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Fil: Abfalterer, Werner. Los Alamos National Laboratory; Estados Unidos
dc.description.fil
Fil: Foley, Brian T.. Los Alamos National Laboratory; Estados Unidos
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Fil: Tegally, Houriiyah. University Of Kwazulu-natal; Sudáfrica
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Fil: San, James Emmanuel. University Of Kwazulu-natal; Sudáfrica
dc.description.fil
Fil: de Oliveira, Tulio. University of KwaZulu-Natal; Sudáfrica
dc.description.fil
Fil: Gnanakaran, Sandrasegaram. Los Alamos National Laboratory; Estados Unidos
dc.description.fil
Fil: Korber, Bette. Los Alamos National Laboratory; Estados Unidos. New Mexico Consortium; México
dc.journal.title
Cell Host & Microbe
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.chom.2021.05.012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00240-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312821002407%3Fshowall%3Dtrue
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