Artículo
A symmetrical dirhenium(I) complex with 4,4''-azobis(2,2'-bipyridine) as a bridging ligand: Synthesis, physicochemical properties and applications in detection of biologically relevant thiols and in chemotherapy for bone cancer
Fecha de publicación:
05/2020
Editorial:
Sociedade Brasileira de Química
Revista:
Journal of the Brazilian Chemical Society
ISSN:
1678-4790
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A new dinuclear complex of formula [{Re(CO)3(py)}2(μ-4,4”-azobpy)](PF6)2, with py = pyridine and 4,4”-azobpy = 4,4”-azobis(2,2'-bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by nuclear magnetic resonance (NMR) measurements. When adding L-cysteine or L-glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data.
Palabras clave:
CHEMOTHERAPY
,
RHENIUM
,
THIOL DETECTION
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INQUINOA)
Articulos de INST.DE QUIMICA DEL NOROESTE
Articulos de INST.DE QUIMICA DEL NOROESTE
Citación
Abate, Pedro Oscar; Sottile, Marco; León, Ignacio E.; Vergara, Mónica M.; Katz, Néstor Eduardo; A symmetrical dirhenium(I) complex with 4,4''-azobis(2,2'-bipyridine) as a bridging ligand: Synthesis, physicochemical properties and applications in detection of biologically relevant thiols and in chemotherapy for bone cancer; Sociedade Brasileira de Química; Journal of the Brazilian Chemical Society; 31; 11; 5-2020; 2299-2306
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