Artículo
Recalibrating immunity in cancer and autoimmune inflammation by lectin-driven regulatory circuits
Bach, Camila Agustina; Cutine, Anabela María
; Laporte, Lorena
; Mahmoud, Yamil Damián
; Manselle Cocco, Montana Nicolle
; Massaro, Mora
; Merlo, Joaquín Pedro
; Perrotta, Ramiro Martin
; Sarbia, Nicolás
; Veigas, Florencia
; Rabinovich, Gabriel Adrián
Fecha de publicación:
12/2020
Editorial:
Centro Redes
Revista:
Science Reviews: from the end of the world
ISSN:
2683-9288
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Endogenous lectins play key roles in cell homeostasis by decoding the informationencrypted in glycans present on the cell surface or extracellular matrix. Galectins, a familyof soluble lectins, have emerged as central regulators of innate and adaptive immuneresponses. In this article we review seminal work demonstrating the immunoregulatoryroles of Galectin-1 (Gal-1), a proto-type member of the galectin family, and highlightcentral mechanisms that control its functions in cancer and autoimmune inflammation.Understanding the cellular pathways that control Gal-1 expression and function in tumorand inflammatory microenvironments will set the bases for the design of rational therapiesbased on positive or negative modulation of this endogenous lectin in cancer andautoimmune diseases.
Palabras clave:
IMMUNOMODULATION
,
CANCER
,
AUTOIMMUNITY
,
GALECTINS
,
CANCER
,
METASTASIS
,
INFLAMMATION
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Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Bach, Camila Agustina; Cutine, Anabela María; Laporte, Lorena; Mahmoud, Yamil Damián; Manselle Cocco, Montana Nicolle; et al.; Recalibrating immunity in cancer and autoimmune inflammation by lectin-driven regulatory circuits; Centro Redes; Science Reviews: from the end of the world; 2; 1; 12-2020; 42-63
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