Artículo
The paradoxical roles of inflammation during PD-1 blockade in cancer
Fecha de publicación:
09/2020
Editorial:
Elsevier
Revista:
Trends In Immunology
ISSN:
1471-4906
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target different subsets of exhausted CD8+ T cells, we propose that the timing at which anti-PD-1 Ab therapy and cytokine modulation occur might determine the fate of exhausted CD8+ T cells and perhaps, the clinical outcome of immunotherapeutic modalities.
Palabras clave:
INFLAMMATION
,
IMMUNE CHECKPOINT BLOCKERS
,
PD-1
,
INFLAMMASOME
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Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Hill, Marcelo; Segovia, Mercedes; Russo, Sofía; Girotti, Maria Romina; Rabinovich, Gabriel Adrián; The paradoxical roles of inflammation during PD-1 blockade in cancer; Elsevier; Trends In Immunology; 41; 11; 9-2020; 982-993
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