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dc.contributor.author
Intebi, Alberto D.
dc.contributor.author
Garau, Laura
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Brusco, Ignacio
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Pagano, Miguel
dc.contributor.author
Gaillard, Rolf C.
dc.contributor.author
Spinedi, Eduardo Julio
dc.date.available
2021-10-03T01:24:36Z
dc.date.issued
2003-12
dc.identifier.citation
Intebi, Alberto D.; Garau, Laura; Brusco, Ignacio; Pagano, Miguel; Gaillard, Rolf C.; et al.; Alzheimer's disease patients display gender dimorphism in circulating anorectic adipokines; Karger; NeuroImmunoModulation; 10; 6; 12-2003; 351-358
dc.identifier.issn
1021-7401
dc.identifier.uri
http://hdl.handle.net/11336/142379
dc.description.abstract
Among neurodegenerative diseases, Alzheimer's disease (AD) is a leading cause of death in elderly individuals. AD is characterized, among other clinical findings, by unexplained weight loss, cachexia and altered immune function. To explore whether any relationship between gender and circulating levels of several eating-controlling metabolites exist, we evaluated leptin, tumor necrosis factor (TNF)-α, triiodothyronine (T3), free (F) thyroxine (T4), TSH, PRL, insulin (INS), and cortisol in 15 AD-treated patients (age range 55-82 years): 9 postmenopausal females (without hormone replacement therapy) and 6 males. The results (mean ± SEM) indicated that circulating leptin levels were significantly (p < 0.05) higher in female AD (40.34 ± 11.1 ng/ml) than in male AD (6.07 ± 1.39 ng/ml) patients. The difference found in circulating leptin levels was noticed regardless of BMI (26.75 ± 1.77 and 24.55 ± 1.93 kg/m 2, in females and males, respectively) and waist:hip ratios (0.91 ± 0.03 and 0.94 ± 0.02, in females and males, respectively). Moreover, serum TNF-α concentrations were also significantly (p < 0.02) higher in AD females (12.24 ± 1.47 pg/ml) than in AD males (6.62 ± 1.44 pg/ml), regardless of TNF-α:BMI ratios (0.50 ± 0.09 and 0.28 ± 0.08, in females and males, respectively; p > 0.05). Finally, no differences were observed between gender (in female and male AD patients, respectively) in circulating levels of T3 (151.33 ± 9.91 vs. 116 ± 17.04 ng/dl), FT4 (1.26 ± 0.08 vs. 1.24 ± 0.06 ng/dl), TSH (1.28 ± 0.16 vs. 2.46 ± 0.67 μlU/ml), PRL (10.53 ± 2.47 vs. 12.61 ± 2.37 ng/ml), INS (11.76 ± 1.95 vs. 8.59 ± 1.34 μlU/ml) and cortisol (15.71 ± 1.23 vs. 12.63 ± 1.47 μg/dl). These results indicate that our AD group of patients, with normal corticoadrenal and thyroid functions and normoprolactinemia, displayed a gender-related characteristic in the circulating levels of two very important anorectic signals, leptin and TNF-α, being both higher in female than in male AD patients, regardless of BMI. Our study suggests that increased circulating levels of both anorexigenic adipokines may contribute to the metabolic changes observed in AD females.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGING
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CYTOKINE
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DEMENTIA
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INFLAMMATION
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LEPTIN
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TNF-Α
dc.subject.classification
Endocrinología y Metabolismo
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Alzheimer's disease patients display gender dimorphism in circulating anorectic adipokines
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-27T15:27:42Z
dc.journal.volume
10
dc.journal.number
6
dc.journal.pagination
351-358
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Intebi, Alberto D.. Clínica de Endocrinología y Metabolismo Dr. J. Reforzo Membrives; Argentina. Gobierno de la Ciudad Autónoma de Buenos Aires. Programa de Investigación en Neurociencias y Salud Mental; Argentina
dc.description.fil
Fil: Garau, Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
dc.description.fil
Fil: Brusco, Ignacio. Gobierno de la Ciudad Autónoma de Buenos Aires. Programa de Investigación en Neurociencias y Salud Mental; Argentina
dc.description.fil
Fil: Pagano, Miguel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
dc.description.fil
Fil: Gaillard, Rolf C.. Universite de Lausanne; Suiza
dc.description.fil
Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
dc.journal.title
NeuroImmunoModulation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/71476
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000071476
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