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dc.contributor.author
Medina, Candela
dc.contributor.author
de la Fuente, Verónica
dc.contributor.author
tom Dieck, Susanne
dc.contributor.author
Nassim Assir, Belquis
dc.contributor.author
Dalmay, Tamas
dc.contributor.author
Bartnik, Ina
dc.contributor.author
Lunardi, Paula Santana
dc.contributor.author
de Oliveira Alvares, Lucas
dc.contributor.author
Schuman, Erin M.
dc.contributor.author
Letzkus, Johannes J.
dc.contributor.author
Romano, Arturo Gabriel
dc.date.available
2021-10-02T01:24:50Z
dc.date.issued
2020-07-11
dc.identifier.citation
Medina, Candela; de la Fuente, Verónica; tom Dieck, Susanne; Nassim Assir, Belquis; Dalmay, Tamas; et al.; LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 173; 107275; 11-7-2020; 1-13
dc.identifier.issn
1074-7427
dc.identifier.uri
http://hdl.handle.net/11336/142334
dc.description.abstract
Long-term memory has been associated with morphological changes in the brain, which in turn tightly correlate with changes in synaptic efficacy. Such plasticity is proposed to rely on dendritic spines as a neuronal canvas on which these changes can occur. Given the key role of actin cytoskeleton dynamics in spine morphology, major regulating factors of this process such as Cofilin 1 (Cfl1) and LIM kinase (LIMK), an inhibitor of Cfl1 activity, are prime molecular targets that may regulate dendritic plasticity. Using a contextual fear conditioning paradigm in mice, we found that pharmacological induction of depolymerization of actin filaments through the inhibition of LIMK causes an impairment in memory reconsolidation, as well as in memory consolidation. On top of that, Cfl1 activity is inhibited and its mRNA is downregulated in CA1 neuropil after re-exposure to the training context. Moreover, by pharmacological disruption of actin cytoskeleton dynamics, the process of memory extinction can either be facilitated or impaired. Our results lead to a better understanding of the role of LIMK, Cfl1 and actin cytoskeleton dynamics in the morphological and functional changes underlying the synaptic plasticity of the memory trace.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COFILIN
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CONSOLIDATION
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EXTINCTION
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FEAR MEMORY
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LIMK
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RECONSOLIDATION
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T18:35:02Z
dc.journal.volume
173
dc.journal.number
107275
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Medina, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: de la Fuente, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: tom Dieck, Susanne. Max Planck Institute for Brain Research; Alemania
dc.description.fil
Fil: Nassim Assir, Belquis. Max Planck Institute for Brain Research; Alemania
dc.description.fil
Fil: Dalmay, Tamas. Max Planck Institute for Brain Research; Alemania
dc.description.fil
Fil: Bartnik, Ina. Max Planck Institute for Brain Research; Alemania
dc.description.fil
Fil: Lunardi, Paula Santana. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: de Oliveira Alvares, Lucas. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Schuman, Erin M.. Max Planck Institute for Brain Research; Alemania
dc.description.fil
Fil: Letzkus, Johannes J.. Max Planck Institute for Brain Research; Alemania
dc.description.fil
Fil: Romano, Arturo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Neurobiology of Learning and Memory
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.nlm.2020.107275
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1074742720301192?via%3Dihub
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