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dc.contributor.author Riveiro, Maria Eugenia
dc.contributor.author de Kimpe, N.
dc.contributor.author Moglioni, Albertina Gladys
dc.contributor.author Vazquez, Ramiro
dc.contributor.author Monczor, Federico
dc.contributor.author Shayo, Carina Claudia
dc.contributor.author Davio, Carlos Alberto
dc.date.available 2017-03-22T22:10:18Z
dc.date.issued 2010-12
dc.identifier.citation Riveiro, Maria Eugenia; de Kimpe, N.; Moglioni, Albertina Gladys; Vazquez, Ramiro; Monczor, Federico; et al.; Coumarins: old compounds with novel promising therapeutic perspectives; Bentham Science Publishers; Current Medicinal Chemistry; 17; 13; 12-2010; 1325-1338
dc.identifier.issn 0929-8673
dc.identifier.uri http://hdl.handle.net/11336/14225
dc.description.abstract Natural as well as synthetic coumarins have recently drawn much attention due to its broad pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti-tumor, anti-viral, anti-inflammatory and antioxidant effects, as well as anti-microbial and enzyme inhibition properties. The recognition of key structural features within coumarin family is crucial for the design and development of new analogues with improved activity and for the characterization of their mechanism of action and potential side effects. The different substituents in the coumarin nucleus strongly influence the biological activity of the resulting derivatives. Although some coumarins have been already characterized to evoke a particular biological activity, the challenge would be the design and synthesis of new derivatives with high specific activity for other pharmacological targets and define their mechanism of action to achieve new therapeutic drugs. The present review highligts the current progress in the development of coumarin scaffolds for drug discovery as novel anti-cancer agents. The major challenges about coumarins include the translation of current knowledge into new potential lead compounds and the repositioning of known compounds for the treatment of cancer.
dc.format application/pdf
dc.language.iso eng
dc.publisher Bentham Science Publishers
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject COUMARINS
dc.subject STRUCTURE ACTIVITY RELATIONSHIP
dc.subject LEAD COMPOUND
dc.subject DRUG DEVELOPMENT
dc.subject.classification Farmacología y Farmacia
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Coumarins: old compounds with novel promising therapeutic perspectives
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-03-21T20:12:03Z
dc.identifier.eissn 1875-533X
dc.journal.volume 17
dc.journal.number 13
dc.journal.pagination 1325-1338
dc.journal.pais Emiratos Árabes Unidos
dc.journal.ciudad Sharjah
dc.description.fil Fil: Riveiro, Maria Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: de Kimpe, N.. University of Ghent; Bélgica
dc.description.fil Fil: Moglioni, Albertina Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina
dc.description.fil Fil: Vazquez, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina
dc.description.fil Fil: Monczor, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina
dc.description.fil Fil: Shayo, Carina Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil Fil: Davio, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina
dc.journal.title Current Medicinal Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/71351/article
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/092986710790936284


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)