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dc.contributor.author
Riveiro, Maria Eugenia  
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de Kimpe, N.  
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Moglioni, Albertina Gladys  
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Vazquez, Ramiro  
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Monczor, Federico  
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Shayo, Carina Claudia  
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Davio, Carlos Alberto  
dc.date.available
2017-03-22T22:10:18Z  
dc.date.issued
2010-12  
dc.identifier.citation
Riveiro, Maria Eugenia; de Kimpe, N.; Moglioni, Albertina Gladys; Vazquez, Ramiro; Monczor, Federico; et al.; Coumarins: old compounds with novel promising therapeutic perspectives; Bentham Science Publishers; Current Medicinal Chemistry; 17; 13; 12-2010; 1325-1338  
dc.identifier.issn
0929-8673  
dc.identifier.uri
http://hdl.handle.net/11336/14225  
dc.description.abstract
Natural as well as synthetic coumarins have recently drawn much attention due to its broad pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti-tumor, anti-viral, anti-inflammatory and antioxidant effects, as well as anti-microbial and enzyme inhibition properties. The recognition of key structural features within coumarin family is crucial for the design and development of new analogues with improved activity and for the characterization of their mechanism of action and potential side effects. The different substituents in the coumarin nucleus strongly influence the biological activity of the resulting derivatives. Although some coumarins have been already characterized to evoke a particular biological activity, the challenge would be the design and synthesis of new derivatives with high specific activity for other pharmacological targets and define their mechanism of action to achieve new therapeutic drugs. The present review highligts the current progress in the development of coumarin scaffolds for drug discovery as novel anti-cancer agents. The major challenges about coumarins include the translation of current knowledge into new potential lead compounds and the repositioning of known compounds for the treatment of cancer.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Bentham Science Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Coumarins  
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Structure Activity Relationship  
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Lead Compound  
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Drug Development  
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Farmacología y Farmacia  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Coumarins: old compounds with novel promising therapeutic perspectives  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-03-21T20:12:03Z  
dc.identifier.eissn
1875-533X  
dc.journal.volume
17  
dc.journal.number
13  
dc.journal.pagination
1325-1338  
dc.journal.pais
Emiratos Árabes Unidos  
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Sharjah  
dc.description.fil
Fil: Riveiro, Maria Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina  
dc.description.fil
Fil: de Kimpe, N.. University of Ghent; Bélgica  
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Fil: Moglioni, Albertina Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina  
dc.description.fil
Fil: Vazquez, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina  
dc.description.fil
Fil: Monczor, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina  
dc.description.fil
Fil: Shayo, Carina Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina  
dc.description.fil
Fil: Davio, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina  
dc.journal.title
Current Medicinal Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/71351/article  
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/092986710790936284