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dc.contributor.author
Oliván Viguera, Aida
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Pérez Zabalza, María
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García Mendívil, Laura
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Mountris, Konstantinos A.
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Orós Rodrigo, Sofía
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Ramos Marquès, Estel
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Vallejo Gil, José María
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Fresneda Roldán, Pedro Carlos
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Fañanás Mastral, Javier
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Vázquez Sancho, Manuel
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Matamala Adell, Marta
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Sorribas Berjón, Fernando
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Bellido Morales, Javier André
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Mancebón Sierra, Francisco Javier
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Vaca Núñez, Alexánder Sebastián
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Ballester Cuenca, Carlos
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Marigil, Miguel Ángel
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Pastor, Cristina
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Ordovás, Laura
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Köhler, Ralf
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Diez, Emiliano Raúl
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Pueyo, Esther
dc.date.available
2021-09-30T18:13:57Z
dc.date.issued
2020-11
dc.identifier.citation
Oliván Viguera, Aida; Pérez Zabalza, María; García Mendívil, Laura; Mountris, Konstantinos A.; Orós Rodrigo, Sofía; et al.; Minimally invasive system to reliably characterize ventricular electrophysiology from living donors; Nature Research; Scientific Reports; 10; 1; 11-2020; 1-13
dc.identifier.uri
http://hdl.handle.net/11336/142132
dc.description.abstract
Cardiac tissue slices preserve the heterogeneous structure and multicellularity of the myocardium and allow its functional characterization. However, access to human ventricular samples is scarce. We aim to demonstrate that slices from small transmural core biopsies collected from living donors during routine cardiac surgery preserve structural and functional properties of larger myocardial specimens, allowing accurate electrophysiological characterization. In pigs, we compared left ventricular transmural core biopsies with transmural tissue blocks from the same ventricular region. In humans, we analyzed transmural biopsies and papillary muscles from living donors. All tissues were vibratomesliced. By histological analysis of the transmural biopsies, we showed that tissue architecture and cellular organization were preserved. Enzymatic and vital staining methods verifed viability. Optically mapped transmembrane potentials confrmed that action potential duration and morphology were similar in pig biopsies and tissue blocks. Action potential morphology and duration in human biopsies and papillary muscles agreed with published ranges. In both pigs and humans, responses to increasing pacing frequencies and β-adrenergic stimulation were similar in transmural biopsies and larger tissues. We show that it is possible to successfully collect and characterize tissue slices from human myocardial biopsies routinely extracted from living donors, whose behavior mimics that of larger myocardial preparations both structurally and electrophysiologically.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MYOCARDIAL SLICE
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ELECTROPHYSIOLOGY
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LIVING DONORS
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ACTION POTENTIALS
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Minimally invasive system to reliably characterize ventricular electrophysiology from living donors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T19:58:02Z
dc.identifier.eissn
2045-2322
dc.journal.volume
10
dc.journal.number
1
dc.journal.pagination
1-13
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Oliván Viguera, Aida. Universidad de Zaragoza; España
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Fil: Pérez Zabalza, María. Universidad de Zaragoza; España
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Fil: García Mendívil, Laura. Universidad de Zaragoza; España
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Fil: Mountris, Konstantinos A.. Universidad de Zaragoza; España
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Fil: Orós Rodrigo, Sofía. Universidad de Zaragoza; España
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Fil: Ramos Marquès, Estel. Universidad de Zaragoza; España
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Fil: Vallejo Gil, José María. University Hospital Miguel Servet; España
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Fil: Fresneda Roldán, Pedro Carlos. University Hospital Miguel Servet; España
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Fil: Fañanás Mastral, Javier. University Hospital Miguel Servet; España
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Fil: Vázquez Sancho, Manuel. University Hospital Miguel Servet; España
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Fil: Matamala Adell, Marta. University Hospital Miguel Servet; España
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Fil: Sorribas Berjón, Fernando. University Hospital Miguel Servet; España
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Fil: Bellido Morales, Javier André. University Hospital Miguel Servet; España
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Fil: Mancebón Sierra, Francisco Javier. University Hospital Miguel Servet; España
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Fil: Vaca Núñez, Alexánder Sebastián. University Hospital Miguel Servet; España
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Fil: Ballester Cuenca, Carlos. University Hospital Miguel Servet; España
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Fil: Marigil, Miguel Ángel. Hospital San Jorge; España
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Fil: Pastor, Cristina. Aragón Institute of Health Sciences; España
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Fil: Ordovás, Laura. Aragón Agency for Research and Development; España. Universidad de Zaragoza; España
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Fil: Köhler, Ralf. Aragón Institute of Health Sciences; España. Aragón Agency for Research and Development; España
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Fil: Diez, Emiliano Raúl. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Fisiología Humana Normal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Pueyo, Esther. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina; España. Universidad de Zaragoza; España
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-020-77076-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-020-77076-0
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