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dc.contributor.author
Priestap, Horacio A.
dc.contributor.author
Galvis, Adriana
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Rivero, Nathalie
dc.contributor.author
Costantino, Valeria Victoria
dc.contributor.author
Lopez, Luis Alberto
dc.contributor.author
Barbieri, M. Alejandro
dc.date.available
2021-09-30T15:37:49Z
dc.date.issued
2012-05
dc.identifier.citation
Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; et al.; Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells; Elsevier Science; Phytochemistry Letters; 5; 3; 5-2012; 581-585
dc.identifier.issn
1874-3900
dc.identifier.uri
http://hdl.handle.net/11336/142108
dc.description.abstract
Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ARTEMISIA DOUGLASIANA BESSER
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B16 MELANOMA CELLS
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MELAN-A
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MIGRATION
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PROLIFERATION
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SESQUITERPENES
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T20:14:10Z
dc.journal.volume
5
dc.journal.number
3
dc.journal.pagination
581-585
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Priestap, Horacio A.. Florida International University; Estados Unidos
dc.description.fil
Fil: Galvis, Adriana. Florida International University; Estados Unidos
dc.description.fil
Fil: Rivero, Nathalie. Florida International University; Estados Unidos
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Fil: Costantino, Valeria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Lopez, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Barbieri, M. Alejandro. Florida International University; Estados Unidos
dc.journal.title
Phytochemistry Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phytol.2012.05.018
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1874390012001127
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