Artículo
Sustained-release hydrogels of ivermectin as alternative systems to improve the treatment of cutaneous leishmaniasis
Romero, Analía Irma
; Cid, Alicia Graciela
; Minetti, Nicolás E.; Briones Nieva, Cintia Alejandra
; Garcia Bustos, Maria Fernanda
; Gonzo, Elio Emilio
; Villegas, Mercedes
; Bermudez, Jose Maria
Fecha de publicación:
12/2020
Editorial:
Future Medicine
Revista:
Therapeutic Delivery
ISSN:
2041-6008
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Leishmaniasis is a neglected tropical disease and its cutaneous form manifests as ulcers or nodules, generally in exposed parts of the body. This work aimed to develop ivermectin (IVM) thermosensitive hydrogels as topical formulations to improve cutaneous leishmaniasis treatment. Materials & methods: Hydrogels based on poloxamers 407 and 188 with different concentrations of IVM were prepared and rheologically characterized. The IVM release profiles were obtained and mathematically analyzed using the Lumped model. Results: The formulation containing 1.5% w/w of IVM presented an adequate gelling temperature, an optimal complex viscosity and elastic modulus. Hydrogels allowed to modulate the release of IVM. Conclusion: IVM thermosensitive hydrogels can be considered a valuable alternative to improve the treatment of cutaneous leishmaniasis.
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Articulos(INIQUI)
Articulos de INST.DE INVEST.PARA LA INDUSTRIA QUIMICA (I)
Articulos de INST.DE INVEST.PARA LA INDUSTRIA QUIMICA (I)
Articulos(IPE)
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Articulos de INST.DE PATOLOGIA EXPERIMENTAL
Citación
Romero, Analía Irma; Cid, Alicia Graciela; Minetti, Nicolás E.; Briones Nieva, Cintia Alejandra; Garcia Bustos, Maria Fernanda; et al.; Sustained-release hydrogels of ivermectin as alternative systems to improve the treatment of cutaneous leishmaniasis; Future Medicine; Therapeutic Delivery; 11; 12; 12-2020; 779-790
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