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dc.contributor.author
Bindini, Elisa
dc.contributor.author
Chehadi, Zeinab
dc.contributor.author
Faustini, Marco
dc.contributor.author
Albouy, Pierre Antoine
dc.contributor.author
Grosso, David
dc.contributor.author
Cattoni, Andrea
dc.contributor.author
Chanéac, Corinne
dc.contributor.author
Azzaroni, Omar
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dc.contributor.author
Sanchez, Clément
dc.contributor.author
Boissière, Cédric
dc.date.available
2021-09-27T13:11:47Z
dc.date.issued
2020-02-20
dc.identifier.citation
Bindini, Elisa; Chehadi, Zeinab; Faustini, Marco; Albouy, Pierre Antoine; Grosso, David; et al.; Following in situ the degradation of mesoporous silica in biorelevant conditions: At last, a good comprehension of the structure influence; American Chemical Society; ACS Applied Materials & Interfaces; 12; 12; 20-2-2020; 13598-13612
dc.identifier.issn
1944-8244
dc.identifier.uri
http://hdl.handle.net/11336/141556
dc.description.abstract
Mesoporous silica nanoparticles (MSNs) have seen a fast development as drug delivery carriers thanks to their tunable porosity and high loading capacity. The employ of MSNs in biomedical applications requires a good understanding of their degradation behavior both to control drug release and to assess possible toxicity issues on human health. In this work, we study mesoporous silica degradation in biologically relevant conditions through in situ ellipsometry on model mesoporous nanoparticle or continuous thin films, in buffer solution and in media containing proteins. In order to shed light on the structure/dissolution relationship, we performed dissolution experiments far from soluble silicate species saturation. Via a complete decorrelation of dissolution and diffusion contributions, we proved unambiguously that surface area of silica vectors is the main parameter influencing dissolution kinetics, while thermal treatment and open mesoporous network architecture have a minor impact. As a logical consequence of our dissolution model, we proved that the dissolution lag-time can be promoted by selective blocking of the mesopores that limits the access to the mesoporous internal surface. This study was broadened by studying the impact of the organosilanes in the silica structure, of the presence of residual structuring agents, and of the chemical composition of the dissolution medium. The presence of albumin at blood concentration was found affecting drastically the dissolution kinetics of the mesoporous structure, acting as a diffusion barrier. Globally, we could identify the main factors affecting mesoporous silica materials degradation and proved that we can tune their structure and composition for adjusting dissolution kinetics in order to achieve efficient drug delivery.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DISSOLUTION KINETIC
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ELLIPSOMETRY
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MESOPOROUS SILICA
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PROTEIN
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THERAPEUTIC VECTORS
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Following in situ the degradation of mesoporous silica in biorelevant conditions: At last, a good comprehension of the structure influence
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T17:27:02Z
dc.journal.volume
12
dc.journal.number
12
dc.journal.pagination
13598-13612
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington
dc.description.fil
Fil: Bindini, Elisa. Sorbonne University; Francia. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Chehadi, Zeinab. Sorbonne University; Francia
dc.description.fil
Fil: Faustini, Marco. Sorbonne University; Francia
dc.description.fil
Fil: Albouy, Pierre Antoine. Université Paris Sud; Francia
dc.description.fil
Fil: Grosso, David. Institut Materiaux Microelectronique Nanoscience de Provence; Francia
dc.description.fil
Fil: Cattoni, Andrea. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Chanéac, Corinne. Sorbonne University; Francia
dc.description.fil
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Sanchez, Clément. Sorbonne University; Francia
dc.description.fil
Fil: Boissière, Cédric. Sorbonne University; Francia
dc.journal.title
ACS Applied Materials & Interfaces
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.9b19956
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acsami.9b19956
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