Mostrar el registro sencillo del ítem

dc.contributor.author
Besuhli, Valeria
dc.contributor.author
de Laurentiis, Andrea
dc.contributor.author
Fernández Solari, Jose Javier
dc.date.available
2017-03-21T21:29:06Z
dc.date.issued
2010-07
dc.identifier.citation
Besuhli, Valeria; de Laurentiis, Andrea; Fernández Solari, Jose Javier; Alcohol and endocannabinoids: neuroendocrine interactions in the reproductive axis; Elsevier Inc; Experimental Neurology; 224; 1; 7-2010; 15-22
dc.identifier.issn
0014-4886
dc.identifier.uri
http://hdl.handle.net/11336/14154
dc.description.abstract
Marihuana and alcohol consumption affect adversely reproduction by inhibiting the hypothalamic–pituitary–gonadal axis. The endocannabinoid system, present in the central nervous system and in peripheral tissues, participates in the regulation of hormones involved in the reproductive physiology such as luteinizing hormone, prolactin and oxytocin. This system is activated in response to pathophysiological conditions such as stress and inflammatory/infectious states as well as alcoholism and drug consumption acting as a negative modulator of reproductive function. The secretion of luteinizing hormone from the adenohypophysis is reduced, mainly through hypothalamic inhibitory action of cannabinoids and alcohol on luteinizing hormone releasing hormone release from its nervous terminals in the median eminence. This inhibitory effect is mediated, at least in part, by the activation of cannabinoid type 1 receptors. Cannabinoids also inhibit prolactin release from the lactotropes in the adenohypophysis acting locally and by increasing the release of hypothalamic dopamine mainly from tuberoinfundibular dopaminergic neurons in the external layer of the median eminence. On the contrary, ethanol stimulates prolactin release from the adenohypophysis as well as oxytocin from the neurohypophysis. Besides, endocannabinoids modulate oxytocin synthesis and release from the hypothalamic magnocellular neurons and neurohypophysis. In summary, all the results exposed in the present review suggest that there is interplay between the endocannabinoid system, hormones and neuropeptides in the control of reproduction and that this system mediates, at least in part, ethanol adverse effects on reproductive function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Ethanol
dc.subject
Endocannabinoids
dc.subject
Hypothalamus
dc.subject
Neurohypophysis
dc.subject
Adenohypophysis
dc.subject
Luteinizing Hormone Releasing Hormone
dc.subject
Prolactin
dc.subject
Oxytocin
dc.subject
Vasopressin
dc.subject.classification
Fisiología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Alcohol and endocannabinoids: neuroendocrine interactions in the reproductive axis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-21T20:11:37Z
dc.journal.volume
224
dc.journal.number
1
dc.journal.pagination
15-22
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Besuhli, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: de Laurentiis, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Fernández Solari, Jose Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Experimental Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014488610001044


Archivos asociados

Documento no disponible

Comunidades y colecciones

Mostrar el registro sencillo del ítem