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dc.contributor.author
Urtreger, Alejandro Jorge
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dc.contributor.author
Kazanietz, Marcelo G.
dc.contributor.author
Bal, Elisa Dora
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dc.date.available
2017-03-20T20:51:41Z
dc.date.issued
2012-01
dc.identifier.citation
Urtreger, Alejandro Jorge; Kazanietz, Marcelo G. ; Bal, Elisa Dora; Contribution of individual PKC isoforms to breast cancer progression; Wiley; IUBMB Life; 64; 1; 1-2012; 18-26
dc.identifier.issn
1521-6543
dc.identifier.uri
http://hdl.handle.net/11336/14122
dc.description.abstract
The protein kinase C (PKC) family of serine/threonine kinases has been intensively studied in cancer since their discovery as major receptors for the tumor-promoting phorbol esters. The contribution of each individual PKC isozyme to malignant transformation is only partially understood, but it is clear that each PKC plays different role in cancer progression. PKC deregulation is a common phenomenon observed in breast cancer, and PKC expression and localization are usually dynamically regulated during mammary gland differentiation and involution. In fact, the overexpression of several PKCs has been reported in malignant human breast tissue and breast cancer cell lines. In this review, we summarize the knowledge available on the specific roles of PKC isoforms in the development, progression, and metastatic dissemination of mammary cancer. We also discuss the role of PKC isoforms as therapeutic targets, and their potential as markers for prognosis or treatment response.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Protein Kinase C
dc.subject
Breast Cancer
dc.subject
Tumor Progression
dc.subject
Prognostic Marker
dc.subject.classification
Otros Tópicos Biológicos
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Contribution of individual PKC isoforms to breast cancer progression
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-20T17:41:16Z
dc.journal.volume
64
dc.journal.number
1
dc.journal.pagination
18-26
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Urtreger, Alejandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina
dc.description.fil
Fil: Kazanietz, Marcelo G. . University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina
dc.journal.title
IUBMB Life
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/iub.574/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/iub.574
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