Artículo
Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency
Ponce, Ivana Tamara; Rezza, Irma Gladys; Delgado, Silvia Marcela; Navigatore Fonzo, Lorena Silvina
; Bonomi, Myrtha Ruth; Golini, Rebeca Laura Susana
; Gimenez, Maria Sofia
; Anzulovich Miranda, Ana Cecilia
Fecha de publicación:
08/2012
Editorial:
Taylor & Francis Ltd
Revista:
Biological Rhythm Research
ISSN:
0929-1016
e-ISSN:
1744-4179
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Examples of hormonal phase-shifting of circadian gene expression began to emerge a few years ago. Vitamin A fulfills a hormonal function by binding of retinoic acid to its nuclear receptors, RARs and RXRs. We found retinoid- as well as clock-responsive sites on regulatory regions of Glutathione reductase (GR) and Glutathione peroxidase (GPx) genes. Interestingly, we observed retinoid receptors, as well as GSH, GR, and GPx, display daily oscillating patterns in the rat liver. We also found that feeding animals with a vitamin A-free diet, dampened daily rhythms of RARα and RXRβ mRNA, GR expression and activity, GSH, BMAL1 protein levels, and locomotor activity. Differently, day- night oscillations of RXRa, GPx mRNA levels and activity and PER1 protein levels, were phase-shifted in the liver of vitamin A-deficient rats. These observations would emphasize the importance of micronutrient vitamin A in the modulation of biological rhythms of GSH and cellular redox state in liver.
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Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Ponce, Ivana Tamara; Rezza, Irma Gladys; Delgado, Silvia Marcela; Navigatore Fonzo, Lorena Silvina; Bonomi, Myrtha Ruth; et al.; Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency; Taylor & Francis Ltd; Biological Rhythm Research; 43; 4; 8-2012; 351-372
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