Artículo
Differences in Epstein-Barr virus characteristics and viral-related microenvironment could be responsible for Lymphomagenesis in children
Vistarop, Aldana Georgina
; Jimenez, Oscar Eduardo
; Cohen, Melina
; de Matteo, Elena Noemí
; Preciado, María Victoria
; Chabay, Paola Andrea
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Fecha de publicación:
01/2020
Editorial:
Molecular Diversity Preservation International
Revista:
Pathogens
ISSN:
2076-0817
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In Argentina, Epstein-Barr virus (EBV) presence is associated with Hodgkin lymphoma (HL) in patients younger than 10 years, suggesting a relationship between low age of EBV infection and HL. Given that HL is derived from germinal centers (GC), our aim was to compare EBV protein expression and microenvironment markers between pediatric HL patients and EBV+GC in children. Methods: EBV presence and immune cell markers were assessed by in situ hybridization and immunohistochemistry (IHC). Results: Viral latency II pattern was proved in all HL patients and in 81.8% of EBV+ tonsillar GCs. LMP1 and LMP2 co-expression were proved in 45.7% HL cases, but only in 7.7% EBV+ GC in pediatric tonsils. An increase in CD4+, IL10, and CD68+ cells was observed in EBV+ GC. In pediatric HL patients, only the mean of IL10+ cells was statistically higher in EBV+ HL. Conclusions: Our findings point us out to suggest that LMP1 expression may be sufficient to drive neoplastic transformation, that an immune regulatory milieu counteracts cytotoxic environment in EBV-associated Hodgkin lymphoma, and that CD4+ and CD68+ cells may be recruited to act in a local collaborative way to restrict, at least in part, viral-mediated lymphomagenesis in tonsillar GC.
Palabras clave:
CHILDREN
,
EBV
,
GERMINAL CENTER
,
HODGKIN LYMPHOMA
,
MICROENVIRONMENT
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Identificadores
Colecciones
Articulos(IMIPP)
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Citación
Vistarop, Aldana Georgina; Jimenez, Oscar Eduardo; Cohen, Melina; de Matteo, Elena Noemí; Preciado, María Victoria; et al.; Differences in Epstein-Barr virus characteristics and viral-related microenvironment could be responsible for Lymphomagenesis in children; Molecular Diversity Preservation International; Pathogens; 9; 1; 1-2020; 1-11
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