Artículo
Distinctive EBV infection characteristics in children from a developing country
Ferressini Gerpe, Natalia Marina
; Vistarop, Aldana Georgina
; Moyano, Agustina Ayelén
; de Matteo, Elena Noemí
; Preciado, María Victoria
; Chabay, Paola Andrea
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Fecha de publicación:
04/2020
Editorial:
Elsevier
Revista:
International Journal of Infectious Diseases
ISSN:
1201-9712
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: In developing countries, Epstein–Barr virus (EBV) infection is mostly asymptomatic in early childhood. EBV persistence may lead to different malignancies, such as B cell derived lymphomas. In Argentina, most children are seropositive at three years and an increased association between EBV and lymphoma was proved in children under 10 years old by our group. Objective: Our aim was to characterize EBV infection at the site of entry and reactivation of viral infection —the tonsils— in order to better understand the mechanism of viral persistence in pediatric patients. Methods: A cohort of 54 patients was described. We assessed specific antibodies profiles in sera; viral proteins presence by IHC on FFPE samples and EBV type from fresh tissue. Results: EBV type 1 was prevalent, mostly in the youngest patients. Asymptomatic primary infected patients presented higher viral loads and Latency 0/I or II patterns, whereas the Latency III pattern was observed mostly in healthy carriers. There were no differences between groups in the expression of viral lytic antigens. This study discloses new features in patients undergoing primary infection from a developing population. Low viral inoculum and restricted viral antigen expression may be responsible for the lack of symptoms in children from our country.
Palabras clave:
ASYMPTOMATIC
,
EBV
,
PEDIATRIC
,
PERSISTENCE
,
PRIMARY INFECTION
,
TONSILS
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Identificadores
Colecciones
Articulos(IMIPP)
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Citación
Ferressini Gerpe, Natalia Marina; Vistarop, Aldana Georgina; Moyano, Agustina Ayelén; de Matteo, Elena Noemí; Preciado, María Victoria; et al.; Distinctive EBV infection characteristics in children from a developing country; Elsevier; International Journal of Infectious Diseases; 93; 4-2020; 139-145
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