Artículo
Galectin-1 impacts on glucose homeostasis by modulating pancreatic insulin release
Sundblad, Victoria
; Garcia Tornadu, Isabel Andrea
; Ornstein, Ana Maria
; Martínez Allo, Verónica Candela
; Lorenzo, Rodrigo Ezequiel; Gatto, Sabrina Gisela
; Morales, Rosa María
; Gambarte Tudela, Julián A; Manselle Cocco, Montana Nicolle
; Croci Russo, Diego Omar
; Becu, Damasia
; Rabinovich, Gabriel Adrián
Fecha de publicación:
2021
Editorial:
Oxford University Press
Revista:
Glycobiology
ISSN:
1460-2423
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Type-2 diabetes mellitus (T2DM) is an expanding global health problem, involving defective insulin secretion by pancreatic β-cells and peripheral insulin resistance, leading to impaired glucose regulation. Galectin-1, an endogenous lectin with affinity for N-acetyllactosamine (LacNAc)-containing glycans, has emerged as a regulator of inflammatory and metabolic disorders. However, the role of galectin-1 in glucose homeostasis and pancreatic β-cell function, independently of hypercaloric diets, has not been explored. Here, we identified a phenotype compatible with T2DM, involving alterations in glucose metabolism and pancreatic insulin release, in female but not male mice lacking galectin-1 (Lgals1-/-). Compared with age-matched controls, Lgals1-/female mice exhibited higher body weight and increased food intake ad libitum as well as after fasting and acute re-feeding. Although fasted serum insulin levels and insulin sensitivity were similar in both genotypes, Lgals1-/- female mice presented altered glucose tolerance and higher basal glucose levels depending on the fasting period. Insulin response to glucose overload was impaired, while pancreatic insulin content was enhanced in the absence of galectin-1. Accordingly, recombinant galectin-1 enhanced glucose-stimulated insulin release in vitro. Our study identifies a role for galectin-1 in regulating glucose metabolism through modulation of pancreatic insulin secretion, highlighting novel opportunities to control T2DM.
Palabras clave:
GALECTIN-1
,
GLUCOSE HOMEOSTASIS
,
INSULIN
,
TYPE-2 DIABETES MELLITUS
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Sundblad, Victoria; Garcia Tornadu, Isabel Andrea; Ornstein, Ana Maria; Martínez Allo, Verónica Candela; Lorenzo, Rodrigo Ezequiel; et al.; Galectin-1 impacts on glucose homeostasis by modulating pancreatic insulin release; Oxford University Press; Glycobiology; 2021
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