Artículo
BSA-capped gold nanoclusters as potential theragnostic for skin diseases: Photoactivation, skin penetration, in vitro, and in vivo toxicity
Lillo, Rolando Cristian Rodrigo
; Calienni, Maria Natalia
; Rivas Aiello, Maria Belen
; Prieto, Maria Jimena
; Rodriguez, Damian
; Tuninetti, Jimena Soledad
; Toledo, Pamela Ludmila
; Alonso, Silvia del Valle
; Moya, Sergio Enrique; Gonzalez, Monica Cristina
; Martinetti Montanari, Jorge Anibal
; Soler Illia, Galo Juan de Avila Arturo
Fecha de publicación:
07/2020
Editorial:
Elsevier Science
Revista:
Materials Science and Engineering: C
ISSN:
0928-4931
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
BSA-capped gold nanoclusters are promising theragnostic systems that can be excited to render both fluorescence emission and reactive oxygen species. Although their synthesis and photoluminescence properties are already well described, more accurate information about their use as photosensitizers is required in order to advance towards health applications. In this work, we have obtained BSA-capped gold nanoclusters and characterized their photophysics by different techniques. Singlet oxygen production was detected upon irradiation, which was enough to produce toxicity on two cell lines. Remarkably, an internal energy transfer, probably due to the presence of smaller nanoclusters and the contribution of oxidized residues of BSA in the system, caused fluorescence emission near 640 nm after excitation in the UV range. Additionally, the system was capable of penetrating human skin beyond the stratum corneum, which enhances the potential of these nanoclusters as bifunctional photodynamic therapy effectors and biomarkers with application in a diversity of skin diseases. In the absence of radiation, BSA-capped gold nanoclusters did not cause toxicity in vitro, while their toxic effect on an in vivo model as zebrafish was determined.
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Lillo, Rolando Cristian Rodrigo; Calienni, Maria Natalia; Rivas Aiello, Maria Belen; Prieto, Maria Jimena; Rodriguez, Damian; et al.; BSA-capped gold nanoclusters as potential theragnostic for skin diseases: Photoactivation, skin penetration, in vitro, and in vivo toxicity; Elsevier Science; Materials Science and Engineering: C; 112; 7-2020; 1-31
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